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MAP1LC3B2 Knockout Cell Lines

Gene: MAP1LC3B2

Official Full Name: microtubule associated protein 1 light chain 3 beta 2provided by HGNC

Gene Summary: Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in cellular response to nitrogen starvation and macroautophagy. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00108 MAP1LC3B2 Knockout cell line (HeLa) Human MAP1LC3B2 1:3~1:6 Negative Online Inquiry
KO08420 MAP1LC3B2 Knockout cell line (HCT 116) Human MAP1LC3B2 1:2~1:4 Negative Online Inquiry
KO08421 MAP1LC3B2 Knockout cell line (HEK293) Human MAP1LC3B2 1:3~1:6 Negative Online Inquiry
KO08422 MAP1LC3B2 Knockout cell line (A549) Human MAP1LC3B2 1:3~1:4 Negative Online Inquiry

Background

MAP1LC3B2 gene knockout cell lines are specialized biological reagents engineered to inhibit the expression of the MAP1LC3B2 gene, which plays a critical role in the autophagy process within cells. By utilizing CRISPR/Cas9 technology or other gene-editing techniques, these cell lines provide a powerful tool for researchers studying cellular mechanisms associated with autophagy, a vital process implicated in cellular homeostasis, stress response, and disease pathogenesis.

The fundamental function of these knockout cell lines lies in their ability to elucidate the consequences of MAP1LC3B2 disruption on various cellular pathways. Researchers can analyze the impact of this gene loss on autophagic flux, organizing insights into how impaired autophagy is linked to conditions such as neurodegeneration, cancer, and infectious diseases. By creating a controlled environment with specific gene silencing, scientists can generate clearer data regarding the functional roles that MAP1LC3B2 plays across diverse biological contexts.

The scientific importance of MAP1LC3B2 knockout cell lines extends to both academic and clinical research. In preclinical studies, these cell lines enable the exploration of novel therapeutic strategies aimed at modulating autophagy as a means of disease intervention. In clinical settings, understanding the dynamics of MAP1LC3B2 can lead to improved diagnostics and personalized treatment approaches for conditions related to defective autophagic processes.

Compared to alternative models, such as transient transfection methods or non-specific gene silencing techniques, MAP1LC3B2 gene knockout cell lines provide a stable, consistent, and long-term platform for observing cellular behaviors and responses. They allow for reproducibility across multiple experiments, offering a high degree of confidence in the gathered data while minimizing experimental variability.

For researchers and clinicians seeking to advance their understanding of autophagy and related diseases, MAP1LC3B2 gene knockout cell lines present an invaluable resource. The ability to selectively disrupt cellular pathways enables groundbreaking discoveries that could lead to targeted therapies and biotechnological advancements.

At our company, we pride ourselves on our commitment to innovation and quality in the production of biological products. Our expertise in genetic engineering and cell line development ensures that our MAP1LC3B2 gene knockout cell lines are of the highest standard, empowering researchers to push the boundaries of scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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