Gene: MAP1A
Official Full Name: microtubule associated protein 1Aprovided by HGNC
Gene Summary: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36720 | MAP1A Knockout cell line (HeLa) | Human | MAP1A | 1:3~1:6 | Negative | Online Inquiry |
KO36721 | MAP1A Knockout cell line (HCT 116) | Human | MAP1A | 1:2~1:4 | Negative | Online Inquiry |
KO36722 | MAP1A Knockout cell line (HEK293) | Human | MAP1A | 1:3~1:6 | Negative | Online Inquiry |
MAP1A Gene Knockout Cell Lines are specialized cell lines engineered to lack the expression of the MAP1A gene, which encodes a critical protein involved in neuronal development and synaptic function. These knockout cell lines serve as an essential tool for researchers aiming to investigate the role of MAP1A in cellular processes such as autophagy, cytoskeletal dynamics, and neurodegenerative diseases. By systematically analyzing the absence of MAP1A, scientists can gain insights into molecular pathways and identify potential therapeutic targets.
The core function of MAP1A Gene Knockout Cell Lines lies in their ability to facilitate the study of gene function through loss-of-function analysis. These modified cells enable the examination of phenotypic changes that occur in the absence of MAP1A, allowing researchers to delve into the intricate relationships between this protein and cellular homeostasis. The specific mechanisms that are uncoupled or altered in these lines provide a wealth of data on cellular regulation and pathways, making them invaluable in both basic and applied research contexts.
In clinical and research settings, MAP1A Gene Knockout Cell Lines are particularly important for modeling neurodevelopmental and neurodegenerative disorders, where the dysregulation of MAP1A has been implicated. By utilizing these cell lines, researchers can develop a better understanding of the pathophysiology of diseases such as Alzheimer's and schizophrenia, paving the way for new diagnostic and therapeutic strategies.
What sets MAP1A Gene Knockout Cell Lines apart from conventional cell lines is their targeted gene editing, which allows for precise manipulation of the MAP1A gene in otherwise identical genetic backgrounds. This specificity reduces off-target effects typically seen in broader genetic modification techniques, leading to more reliable and reproducible results. Additionally, the availability of these knockout lines integrates seamlessly with high-throughput screening platforms, promoting accelerated discovery and validation processes.
For researchers and clinicians alike, the MAP1A Gene Knockout Cell Lines represent a significant advancement in the study of neurobiology, enabling sophisticated experiments that contribute to our understanding of complex diseases. Our company specializes in creating bespoke genetic tools and cell lines that empower the scientific community, supported by our extensive expertise in gene editing technologies and cellular biology. These products are essential for those seeking to push the boundaries of current biological research.
Please note that all services are for research use only. Not intended for any clinical use.
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