Gene: MAGEB2
Official Full Name: MAGE family member B2provided by HGNC
Gene Summary: This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36736 | MAGEB2 Knockout cell line (HCT 116) | Human | MAGEB2 | 1:2~1:4 | Negative | Online Inquiry |
MAGEB2 Gene Knockout Cell Lines are sophisticated research tools derived through targeted gene-editing technologies designed to inactivate the MAGEB2 gene, which belongs to the Melanoma Antigen Gene (MAGE) family. This innovative product allows researchers to explore the biological roles of MAGEB2 in various cellular processes, offering essential insights into its contributions to tumor biology, immune modulation, and potential therapeutic targets for cancer treatment.
Utilizing CRISPR-Cas9 or similar genome editing methodologies, these cell lines ensure a precise knockout of the MAGEB2 gene, facilitating the evaluation of downstream effects on cellular proliferation, differentiation, and signaling pathways. By comparing MAGEB2 knockout cells with wild-type counterparts, researchers can effectively ascertain the gene’s functional relevance and elucidate its role in malignancies, particularly those associated with melanoma. This makes MAGEB2 knockout cell lines indispensable in translational research and drug development.
The scientific importance of MAGEB2 knockout cell lines lies in their applications across various domains, including cancer immunotherapy, pharmacological screening, and gene function studies. As a result, they become crucial in developing novel treatment strategies, elucidating immune escape mechanisms, and exploring the genetic predispositions related to tumor development.
Compared to alternative approaches—such as pharmacological inhibition or overexpression strategies—MAGEB2 knockout cell lines offer a definitive and reproducible means to study gene function without confounding variables. The lineage stability and customizable nature of these lines provide additional value, allowing tailored experiments suited to specific research needs.
For researchers and clinicians, MAGEB2 Gene Knockout Cell Lines are not merely tools but gateways to groundbreaking discoveries in cancer research. Their use can significantly accelerate understanding of the immunogenicity of cancer cells, paving the way for personalized therapies and enhanced treatment protocols.
Our company stands at the forefront of biotechnological innovation, dedicated to providing high-quality biological products that empower researchers in their quest for scientific advancement. With a robust portfolio of advanced gene-editing tools, we are committed to supporting the pursuit of life-changing discoveries in healthcare and disease management.
Please note that all services are for research use only. Not intended for any clinical use.
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