Gene: MADD
Official Full Name: MAP kinase activating death domainprovided by HGNC
Gene Summary: Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05252 | MADD Knockout cell line (HeLa) | Human | MADD | 1:3~1:6 | Negative | Online Inquiry |
KO05253 | MADD Knockout cell line (HCT 116) | Human | MADD | 1:2~1:4 | Negative | Online Inquiry |
KO05254 | MADD Knockout cell line (HEK293) | Human | MADD | 1:3~1:6 | Negative | Online Inquiry |
KO05255 | MADD Knockout cell line (A549) | Human | MADD | 1:3~1:4 | Negative | Online Inquiry |
MADD Gene Knockout Cell Lines are specifically engineered cellular models that have undergone targeted gene disruption of the MADD gene, a critical regulator of apoptosis and cell survival pathways. These knockout cell lines enable researchers to elucidate the role of MADD in cellular processes, allowing for detailed studies of cell signaling mechanisms integral to cancer research, neurobiology, and metabolic studies.
The functionality of MADD Gene Knockout Cell Lines revolves around the loss of MADD protein expression, which leads to alterations in the balance between pro-apoptotic and anti-apoptotic signals within cells. By investigating these modified cells, scientists can observe the impact of MADD depletion on cell proliferation, survival, and response to stressors, facilitating a deeper understanding of malignancies where apoptosis evasion is a hallmark.
The scientific importance of MADD Gene Knockout Cell Lines extends into various research and clinical applications, including drug discovery, where they serve as valuable tools for screening agents that resensitize tumors to apoptosis. This functionality places them at the forefront of therapeutic development, particularly in targeted cancer therapies.
Compared to alternative models, MADD Gene Knockout Cell Lines provide a more precise method for investigating the specific pathways influenced by the absence of MADD, avoiding the confounding results often associated with traditional knockdown techniques. Their stable expression and responsiveness make them a superior choice for experimental consistency and reliability.
For researchers and clinicians seeking to advance their understanding of cell survival mechanisms, MADD Gene Knockout Cell Lines represent an invaluable resource. They empower the investigation of therapeutic targets, potentially leading to breakthrough treatments in cancer and other diseases characterized by dysregulated apoptosis.
At our company, we specialize in the development of high-quality biological products tailored for cutting-edge research, ensuring that our offerings, including MADD Gene Knockout Cell Lines, are backed by rigorous validation and expertise, elevating scientific discovery in life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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