Gene: MACROH2A2
Official Full Name: macroH2A.2 histoneprovided by HGNC
Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Oct 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09778 | MACROH2A2 Knockout cell line (HCT 116) | Human | MACROH2A2 | 1:2~1:4 | Negative | Online Inquiry |
KO09779 | MACROH2A2 Knockout cell line (HEK293) | Human | MACROH2A2 | 1:3~1:6 | Negative | Online Inquiry |
KO09780 | MACROH2A2 Knockout cell line (A549) | Human | MACROH2A2 | 1:3~1:4 | Negative | Online Inquiry |
MACROH2A2 Gene Knockout Cell Lines are engineered cell lines characterized by the targeted deletion of the MACROH2A2 gene, a crucial component in the regulation of chromatin structure and gene expression. This product serves as a powerful tool for researchers to study the role of MACROH2A2 in cellular processes such as gene silencing, DNA repair, and cellular differentiation.
These gene knockout cell lines allow for comprehensive analyses of the functional consequences of MACROH2A2 deficiency. By employing CRISPR-Cas9 technology, our cell lines provide a robust platform to unravel the mechanistic pathways that MACROH2A2 influences, including its effects on transcriptional regulation and genomic stability. Researchers can utilize these cell lines to investigate various biological contexts, including cancer biology, developmental biology, and epigenetic modifications, making the lines highly versatile for a range of studies.
From a scientific standpoint, MACROH2A2 is implicated in significant clinical contexts, including its association with various diseases such as cancer and neurological disorders. The ability to study precise genetic alterations using our knockout cell lines unlocks potential therapeutic insights and opportunities for intervention strategies.
Compared to other gene editing platforms, the MACROH2A2 Gene Knockout Cell Lines offer a unique advantage in ease of use, specificity, and reproducibility. The targeted deletion provides a clearer understanding of gene function relative to other methods that may not knock out the gene completely or may leave compensatory mechanisms intact.
For researchers and clinicians seeking to deepen their understanding of chromatin dynamics, gene regulation, and disease mechanisms, the MACROH2A2 Gene Knockout Cell Lines represent an invaluable resource. Our company specializes in producing high-quality biological products backed by extensive scientific expertise, ensuring that our offerings meet the rigorous demands of advanced research and clinical applications. By choosing our product, researchers will benefit from unparalleled precision and reliability that enhances their pursuit of groundbreaking scientific discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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