Home / MACC1 Knockout Cell Lines

MACC1 Knockout Cell Lines

Gene: MACC1

Official Full Name: MET transcriptional regulator MACC1provided by HGNC

Gene Summary: MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20520 MACC1 Knockout cell line (HCT 116) Human MACC1 1:2~1:4 Negative Online Inquiry

Background

MACC1 Gene Knockout Cell Lines are genetically engineered cell lines designed to specifically disrupt the expression of the MACC1 gene, which has been implicated in various cancers, particularly in promoting tumorigenesis and metastasis. These cell lines serve as powerful tools for researchers seeking to investigate the roles of MACC1 in cellular processes such as proliferation, apoptosis, and invasion. By targeting and knocking out the MACC1 gene, scientists can create in vitro models that closely mimic the conditions of MACC1-related pathologies, enabling a more profound understanding of its biological functions and regulatory mechanisms.

The primary mechanism of action involves the use of CRISPR-Cas9 technology, which allows for precise modifications in the genome, resulting in the elimination of MACC1 expression. This approach not only facilitates the investigation of MACC1's oncogenic potential but also aids in the identification of novel therapeutic targets and biomarkers for cancer treatment and prognosis.

The scientific importance of MACC1 Gene Knockout Cell Lines extends to applications in both research and clinical settings. In preclinical studies, these cell lines can be utilized for drug screening, allowing for the evaluation of potential treatments that inhibit MACC1-associated pathways. Furthermore, their relevance in understanding metastatic behavior positions them as a crucial resource in cancer biology research.

Compared to alternative approaches, such as transient knockdown techniques, MACC1 Gene Knockout Cell Lines provide stable and reproducible results, thus ensuring greater reliability for long-term studies. Researchers benefit from the ability to conduct multiple experiments without the variability often introduced by transient gene silencing methods.

This product is invaluable for researchers and clinicians focused on cancer biology, offering a direct avenue to explore MACC1's implications in health and disease. By incorporating MACC1 Gene Knockout Cell Lines into their research, users gain a comprehensive insight into tumor biology and enhance their potential to translate findings into therapeutic innovations.

Our company stands at the forefront of genetic engineering and molecular biology, consistently delivering high-quality, reliable research tools that empower scientists in their quest for breakthroughs in biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.