Gene: Lats2
Official Full Name: large tumor suppressor 2provided by MGI
Gene Summary: Enables protein serine/threonine kinase activity. Involved in G1/S transition of mitotic cell cycle; negative regulation of protein localization to nucleus; and regulation of signal transduction. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and negative regulation of canonical Wnt signaling pathway. Located in spindle pole. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human LATS2 (large tumor suppressor kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01488 | Lats2 Knockout cell line(4T1) | Mouse | Lats2 | 1:3~1:4 | Negative | Online Inquiry |
Lats2 Gene Knockout Cell Lines are biologically engineered cellular models featuring a targeted disruption of the Lats2 gene, which encodes for a major regulator of the Hippo signaling pathway. This pivotal pathway is crucial for controlling cell proliferation and apoptosis and plays a significant role in organ size regulation and tissue homeostasis. By creating Lats2 knockout cells, researchers can specifically assess the functional impacts of Lats2 deficiency in various biological processes, lending insights into cell growth, tumorigenesis, and regenerative medicine.
The primary function of the Lats2 Gene Knockout Cell Lines is to provide a platform for studying the downstream effects of Hippo signaling perturbation. By knocking out Lats2, researchers can mimic tumor-like environments, enabling the exploration of pathways that lead to enhanced cell survival and increased proliferation. This model is particularly valuable for understanding cancer biology, as dysregulation of the Hippo pathway has been implicated in several malignancies. Additionally, these cell lines facilitate the investigation of potential therapeutic interventions that target Lats2-associated pathways.
Scientifically, Lats2 Gene Knockout Cell Lines hold significant importance for both academic research and clinical applications. In academic settings, they offer a robust model for elucidating cellular mechanisms underlying cancer progression and treatment resistance. Clinically, the insights gained could inform the development of targeted therapies aimed at modulating Hippo signaling, providing a new avenue for treating cancers where the Lats2 gene plays a role.
One of the foremost advantages of using Lats2 Gene Knockout Cell Lines is their specificity and reliability compared to other models that may not accurately represent Lats2's role in cellular processes. Unlike traditional methods, which may involve broad genetic manipulation or overexpression systems, our knockout lines allow researchers to precisely study the absence of Lats2 without confounding variables.
Ultimately, Lats2 Gene Knockout Cell Lines represent a valuable tool for researchers and clinicians committed to advancing the understanding of cellular behavior and cancer therapies. By utilizing our high-quality cell lines, users are equipped to drive innovative discoveries with the potential to improve patient outcomes. Our company, with its strong foundation in genetic engineering and cell line development, is dedicated to providing top-tier biological products that empower scientific advancement.
Please note that all services are for research use only. Not intended for any clinical use.
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