Gene: LZTS3
Official Full Name: leucine zipper tumor suppressor family member 3provided by HGNC
Gene Summary: Predicted to enable PDZ domain binding activity. Predicted to be involved in protein homooligomerization; regulation of dendritic spine morphogenesis; and regulation of postsynapse assembly. Predicted to be located in postsynaptic density. Predicted to be active in dendritic spine and glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32806 | LZTS3 Knockout cell line (HCT 116) | Human | LZTS3 | 1:2~1:4 | Negative | Online Inquiry |
KO32807 | LZTS3 Knockout cell line (HEK293) | Human | LZTS3 | 1:3~1:6 | Negative | Online Inquiry |
KO32808 | LZTS3 Knockout cell line (A549) | Human | LZTS3 | 1:3~1:4 | Negative | Online Inquiry |
LZTS3 Gene Knockout Cell Lines are genetically modified cellular models in which the LZTS3 gene has been systematically disrupted, facilitating the study of its biological functions and implications in various diseases, particularly cancer. This innovative product leverages CRISPR-Cas9 technology to ensure precise knockout of the LZTS3 gene, allowing researchers to explore the gene's role in cellular processes such as proliferation, apoptosis, and tumorigenesis.
The key mechanism involves utilizing a single-guide RNA (sgRNA) that matches the LZTS3 gene’s sequence, coupled with the Cas9 nuclease to induce double-strand breaks. This precise alteration leads to frameshift mutations, effectively silencing the gene. By utilizing these knockout cell lines, researchers can delve into pathways affected by LZTS3 depletion, elucidating its potential as a tumor suppressor and assessing its impact on drug resistance and sensitivity in various therapeutic contexts.
The scientific importance of LZTS3 Gene Knockout Cell Lines cannot be overstated, as they serve as valuable tools in cancer research, molecular biology, and drug discovery pursuits, particularly in understanding the mechanisms that underpin malignancy and treatment resistance. Compared to traditional knockdown approaches, these knockout lines provide a stable and heritable genetic alteration, ensuring more robust experimental outcomes with minimal off-target effects.
An essential advantage of our product is its tailored design to increase reproducibility in experimental data, providing a reliable resource for researchers seeking to understand the precise biological functions of LZTS3 and its relevance in pathology. Additionally, our cell lines are fully characterized, enabling seamless integration into existing workflows and experimental paradigms.
For researchers and clinicians, the LZTS3 Gene Knockout Cell Lines represent a groundbreaking capability in elucidating the complexities of gene function in disease contexts. Our confidence stems from years of experience in cellular biology, ensuring that our products meet the highest standards of quality and efficacy. As a leading provider of genetic models, we are committed to empowering scientific discovery and delivering innovative solutions to enhance your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.