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LRRC8D Knockout Cell Lines

Gene: LRRC8D

Official Full Name: leucine rich repeat containing 8 VRAC subunit Dprovided by HGNC

Gene Summary: Enables volume-sensitive anion channel activity. Involved in several processes, including monoatomic anion transmembrane transport; organic acid transmembrane transport; and protein hexamerization. Located in cytoplasm and plasma membrane. Part of monoatomic ion channel complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16470 LRRC8D Knockout cell line (HeLa) Human LRRC8D 1:3~1:6 Negative Online Inquiry
KO16471 LRRC8D Knockout cell line (HCT 116) Human LRRC8D 1:2~1:4 Negative Online Inquiry
KO16472 LRRC8D Knockout cell line (HEK293) Human LRRC8D 1:3~1:6 Negative Online Inquiry
KO16473 LRRC8D Knockout cell line (A549) Human LRRC8D 1:3~1:4 Negative Online Inquiry

Background

LRRC8D Gene Knockout Cell Lines are meticulously engineered cellular models in which the LRRC8D gene has been inactivated, providing invaluable tools for studying the physiological and pathophysiological functions of this gene. The LRRC8D protein, a member of the leucine-rich repeat-containing (LRRC) protein family, is known to form part of the volume-regulated anion channel, playing a crucial role in cellular ion homeostasis and osmoregulation. The knockout of this gene allows researchers to observe the resultant physiological changes, thereby elucidating the specific contributions of LRRC8D in various cellular processes.

These cell lines can be utilized in a range of applications, from basic research to drug development, particularly in studies related to cell volume regulation, apoptosis, and ion transport mechanisms. Their unique ability to uncover the specific role of LRRC8D in cellular behavior makes them highly valuable in understanding disorders where ion channel dysregulation is implicated, including some forms of cancer and neurodegenerative diseases.

A significant advantage of using LRRC8D Gene Knockout Cell Lines lies in their specificity and precision. Unlike general inhibition techniques, knockout models eliminate the gene's expression entirely, yielding clearer results that facilitate the establishment of direct cause-and-effect relationships. Additionally, these cell lines are rigorously validated for reproducibility and consistency, ensuring that researchers can rely on them for meaningful results.

For researchers and clinicians focused on advancing their understanding of cellular signaling and therapeutic interventions, these knockout cell lines represent a groundbreaking resource that enhances the study of ion channels. Our commitment to providing high-quality biological products, backed by cutting-edge research and development, positions our company as a leader in the field, striving to empower scientific discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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