Gene: LRP2
Official Full Name: LDL receptor related protein 2provided by HGNC
Gene Summary: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10037 | LRP2 Knockout cell line (HEK293) | Human | LRP2 | 1:3~1:6 | Negative | Online Inquiry |
LRP2 Gene Knockout Cell Lines represent a pivotal advancement in cellular biology and genetic research, specifically targeting the low-density lipoprotein receptor-related protein 2 (LRP2) gene. These engineered cell lines are designed to lack the functional LRP2 gene, a crucial component in endocytosis and intracellular signaling pathways that modulate various physiological functions. By effectively removing this gene, researchers can investigate the subsequent phenotypic changes and biochemical pathways influenced by LRP2, thereby illuminating its role in health and disease.
The key functionality of LRP2 Gene Knockout Cell Lines lies in their ability to facilitate comprehensive studies on cellular mechanisms associated with lipoprotein metabolism, cellular stress responses, and signaling cascades. By analyzing the effects of LRP2 ablation, scientists can explore the gene’s contributions to disorders such as atherosclerosis, Alzheimer’s disease, and other metabolic syndromes, providing a refined understanding of these conditions at a molecular level.
In the scientific community, these knockout cell lines are invaluable tools, serving not only in fundamental research but also in the development of targeted therapeutic strategies. The ability to model diseases more closely aligns with results seen in vivo, thus enhancing the reliability of preclinical data. This positions LRP2 Gene Knockout Cell Lines as superior alternatives to traditional models, offering greater specificity and reducing the ambiguity often associated with broader genetic interventions.
One of the foremost advantages of utilizing our LRP2 Gene Knockout Cell Lines is their rigorous validation and optimization, which ensure consistent and reproducible results essential for research integrity. Furthermore, this product encapsulates a rich resource for academic and pharmaceutical entities aiming to expedite discoveries while minimizing the pitfalls of variability often seen in less refined experimental models.
Our company prides itself on a strong foundation in genetic engineering and cell biology, committed to advancing the capabilities of researchers and clinicians alike. By providing high-quality LRP2 Gene Knockout Cell Lines, we support innovative research that promises to bridge the gap between foundational science and clinical application.
Please note that all services are for research use only. Not intended for any clinical use.
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