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LRBA Knockout Cell Lines

Gene: LRBA

Official Full Name: LPS responsive beige-like anchor proteinprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00252 LRBA gRNA5-gRNA6 KO plasmid LRBA $850
GP00385 LRBA gRNA1-gRNA2 KO plasmid LRBA $850
KO00653 LRBA Knockout cell line (Jurkat, Clone E6-1) Human LRBA 1:3-1:5 Negative Online Inquiry
KO02022 LRBA Knockout cell line (HeLa) Human LRBA 1:3~1:6 Negative Online Inquiry
KO02023 LRBA Knockout cell line (HCT 116) Human LRBA 1:2~1:4 Negative Online Inquiry
KO02024 LRBA Knockout cell line (HEK293) Human LRBA 1:3~1:6 Negative Online Inquiry
KO02025 LRBA Knockout cell line (A549) Human LRBA 1:3~1:4 Negative Online Inquiry

Background

LRBA Gene Knockout Cell Lines are specialized biological tools designed for the investigation of the function of the LRBA gene, which is critical in the immune response and cellular homeostasis. Utilizing CRISPR-Cas9 technology, these cell lines have been engineered to disrupt the LRBA gene, thereby allowing researchers to study the resulting phenotypic changes and elucidate the gene’s role in various biological processes.

The key functions of LRBA Gene Knockout Cell Lines lie in their ability to mimic genetic conditions associated with LRBA deficiency, a disorder linked to immunodeficiency and autoimmune diseases. By providing a model for loss-of-function studies, these cell lines facilitate investigations into the mechanisms of immune regulation and cell signaling pathways affected by LRBA's absence. This can help elucidate the pathophysiology of related diseases and guide therapeutic developments.

In research and clinical settings, the scientific importance of LRBA Gene Knockout Cell Lines is particularly evident in the study of both innate and adaptive immunity. They serve as valuable platforms for testing potential treatments and interventions, contributing to the development of targeted therapies for patients with LRBA-related immune disorders. Furthermore, these cell lines expand the toolkit available to researchers studying gene function, disease mechanisms, and potential gene editing applications.

Compared to traditional knockout models, LRBA Gene Knockout Cell Lines offer several advantages, including a streamlined generation process, reproducibility, and the ability to be used in high-throughput screening assays. Their ease of use also allows for quicker data collection and analysis, enhancing experimental efficiency.

For researchers and clinicians operating in the fields of immunology and genetic research, the value of LRBA Gene Knockout Cell Lines cannot be overstated. They provide a robust platform for advancing our understanding of complex immune responses, ultimately leading to better patient care and innovative therapies.

Our company, with its expertise in gene editing technologies and a commitment to advancing biological research, ensures that our offerings, including the LRBA Gene Knockout Cell Lines, meet the highest standards for scientific integrity and functionality, supporting the ongoing quest for knowledge in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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