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LPAR2 Knockout Cell Lines

Gene: LPAR2

Official Full Name: lysophosphatidic acid receptor 2provided by HGNC

Gene Summary: This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10233 LPAR2 Knockout cell line (HeLa) Human LPAR2 1:3~1:6 Negative Online Inquiry
KO10234 LPAR2 Knockout cell line (HCT 116) Human LPAR2 1:2~1:4 Negative Online Inquiry
KO10235 LPAR2 Knockout cell line (HEK293) Human LPAR2 1:3~1:6 Negative Online Inquiry
KO10236 LPAR2 Knockout cell line (A549) Human LPAR2 1:3~1:4 Negative Online Inquiry

Background

LPAR2 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to lack functional expression of the lysophosphatidic acid receptor 2 (LPAR2). This receptor plays a crucial role in various physiological and pathological processes, including cell proliferation, differentiation, and migration. Creating knockout versions of LPAR2 enables researchers to dissect its role in signaling pathways, providing insights into its contributions to cancer, fibrosis, and neurodegenerative diseases.

These cell lines function by utilizing CRISPR/Cas9 technology to achieve precise and efficient gene editing, ensuring complete ablation of LPAR2 expression. The resulting models facilitate the study of LPAR2-mediated signaling pathways, allowing scientists to investigate how the absence of this receptor impacts cellular behavior. Researchers can conduct experiments to analyze cellular responses to various stimuli and evaluate the biological consequences in disease states, which is vital for drug discovery and therapeutic development.

The scientific importance of LPAR2 Gene Knockout Cell Lines lies in their utility for unraveling complex biological mechanisms that underlie diseases linked to LPAR2. Their applications span various domains, including cancer research, neurobiology, and regenerative medicine, making them a versatile tool for advancing scientific knowledge and therapeutic innovations.

Compared to alternative models like wild-type or overexpressing systems, these knockout cell lines provide a more authentic depiction of the receptor's absence, eliminating compensatory mechanisms that can confound results. Additionally, the specificity of CRISPR technology minimizes off-target effects, thus enhancing the reliability of experimental outcomes.

For researchers and clinicians focused on elucidating the biological impacts of LPAR2, these knockout cell lines are an invaluable resource, empowering them to make groundbreaking discoveries in their respective fields. Our company has a strong commitment to advancing biotechnological innovations, ensuring that you have access to high-quality, reliable products that enhance your research capabilities. By choosing LPAR2 Gene Knockout Cell Lines, you are equipping yourself with a cutting-edge tool designed to accelerate your scientific inquiries and therapeutic advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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