Gene: LMO2
Official Full Name: LIM domain only 2provided by HGNC
Gene Summary: LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36804 | LMO2 Knockout cell line (HCT 116) | Human | LMO2 | 1:2~1:4 | Negative | Online Inquiry |
LMO2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the LMO2 gene, which plays a crucial role in hematopoietic development and leukemogenesis. The LMO2 gene is implicated in several forms of leukemia, making these knockouts invaluable for studying both normal hematopoiesis and the mechanisms of malignant transformation. Through the use of CRISPR/Cas9 gene-editing technology, these cell lines are created to provide a precise, reliable system for exploring the functional consequences of LMO2 loss, thereby broadening the understanding of its involvement in blood disorders.
The key functions of LMO2 Gene Knockout Cell Lines include enabling targeted gene function studies, assessing the impact of LMO2 loss on cellular differentiation, proliferation, and survival. They also serve as an experimental platform for testing potential therapeutic interventions that could reverse the effects of LMO2 dysregulation. Such models are indispensable in both basic research and drug discovery, allowing researchers to identify new therapeutic targets and validate the efficacy of small-molecule inhibitors in a controlled setting.
Scientifically, these knockout cell lines represent a significant advancement in the field of hematology and oncology research. They allow for in-depth studies on the intricate pathways involving LMO2, thus contributing to the broader understanding of its role in malignant disease progression. Compared to traditional cell lines that express LMO2, these knockout models provide a unique opportunity to investigate the specific contributions of this gene to disease pathology, which is often masked in wild-type scenarios.
The unique selling points of our LMO2 Gene Knockout Cell Lines lie in their authenticity and high-quality generation, ensuring consistent results across experiments. Unlike alternative models, our lines are thoroughly characterized, providing assurance of specificity and reliability that is crucial for experimental reproducibility.
Targeted toward researchers and clinicians, this product not only elevates the quality of research outputs but also enhances the potential for developing next-generation therapies for leukemia patients. By investing in our LMO2 Gene Knockout Cell Lines, you are equipping your research with the precision tools needed to make meaningful contributions to the field.
At our company, we pride ourselves on our expertise in genetic engineering and the production of high-quality biological products. Our commitment to advancing research through precise and reliable tools ensures that researchers can remain at the forefront of scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.