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LIMA1 Knockout Cell Lines

Gene: LIMA1

Official Full Name: LIM domain and actin binding 1provided by HGNC

Gene Summary: This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16546 LIMA1 Knockout cell line (HeLa) Human LIMA1 1:3~1:6 Negative Online Inquiry
KO16547 LIMA1 Knockout cell line (HEK293) Human LIMA1 1:3~1:6 Negative Online Inquiry
KO16548 LIMA1 Knockout cell line (A549) Human LIMA1 1:3~1:4 Negative Online Inquiry
KO39164 LIMA1 Knockout cell line (HCT 116) Human LIMA1 1:2~1:4 Negative Online Inquiry

Background

LIMA1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the LIMA1 gene, which encodes a protein involved in cytoskeletal organization and cell signaling. These cell lines serve as valuable tools for studying the functional roles of LIMA1 in various biological processes, such as cell motility, adhesion, and cancer progression. By utilizing advanced gene editing techniques, such as CRISPR/Cas9, these cell lines allow researchers to dissect the molecular pathways influenced by LIMA1, providing insights into its contributions to cellular dynamics and behavior.

The key functions of LIMA1 include its involvement in actin filament organization, as well as its regulatory effects on focal adhesions. The knockout of this gene facilitates a clearer understanding of how its absence alters phenotypes and cellular responses to external stimuli. In research settings, these models can be instrumental in elucidating the pathological roles of LIMA1 in diseases like cancer, where altered cell migration and invasion are critical factors.

Scientifically, LIMA1 Gene Knockout Cell Lines hold significant importance as they can be utilized to explore therapeutic targets and assess drug efficacy in modulating pathways associated with cell adhesion and metastasis. These cell lines offer a distinct advantage over conventional wild-type models, as they allow for controlled experiments that analyze the direct effects of LIMA1 knockout on cellular behavior. They represent an innovative approach to dissecting complex biological questions in a more streamlined and targeted manner.

For researchers and clinicians alike, the value of LIMA1 Gene Knockout Cell Lines lies in their ability to provide precise insights and enhance the accuracy of findings in studies related to cancer biology and cellular mechanisms. The capability to tailor experiments based on specific gene knockouts positions these cell lines as powerful assets in translational research.

Our company specializes in high-quality biological products, backed by cutting-edge research and a commitment to advancing scientific innovation. By offering reliable and accessible models like the LIMA1 Gene Knockout Cell Lines, we aim to support the scientific community in making breakthroughs that can translate into real-world applications.

Please note that all services are for research use only. Not intended for any clinical use.

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