Gene: LHX9
Official Full Name: LIM homeobox 9provided by HGNC
Gene Summary: This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16553 | LHX9 Knockout cell line (HeLa) | Human | LHX9 | 1:3~1:6 | Negative | Online Inquiry |
LHX9 Gene Knockout Cell Lines are genetically engineered cell lines that have had the LHX9 gene specifically disrupted, providing a powerful tool for researchers investigating the role of this transcription factor in various biological processes. LHX9 is implicated in neurogenesis and the development of the central nervous system, making its knockout essential for studying developmental biology and genetic pathologies related to neural differentiation.
These cell lines function by utilizing CRISPR-Cas9 technology to create precise deletions or mutations in the LHX9 gene, leading to a loss of function. This enables scientists to observe the resultant phenotypic changes and to elucidate the gene's specific contributions to cellular processes such as signaling pathways, cell proliferation, and differentiation. The ability to study these alterations in a controlled environment offers unprecedented insight into the genetic underpinnings of diseases, particularly those affecting neural development, thus paving the way for potential therapeutic approaches.
Scientifically, LHX9 Gene Knockout Cell Lines have crucial applications in both research and clinical settings. They are particularly valuable in the fields of neurobiology, cancer research, and regenerative medicine, where understanding the effects of gene loss on cell behavior can lead to significant breakthroughs. Furthermore, these cell lines allow for high-throughput screening of small molecules or compounds that may modulate the pathways affected by LHX9, facilitating drug discovery and development.
The advantages of using LHX9 Gene Knockout Cell Lines over traditional wild-type cell models are manifold. They offer unique insights into gene function that cannot be achieved with overexpression systems or non-targeted genetic modifications. Researchers benefit from high reproducibility and reliability of experimental results, reducing variability and increasing experimental throughput.
The value proposition for researchers and clinicians is clear: these specialized cell lines provide a critical foundation for advancing our understanding of gene function and disease mechanisms, ultimately leading to more targeted and effective strategies in disease treatment and management. Our company prides itself on its expertise in CRISPR technology and the development of robust genetic tools, ensuring that our LHX9 Gene Knockout Cell Lines meet the highest standards for scientific rigor and reproducibility.
Please note that all services are for research use only. Not intended for any clinical use.
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