Gene: LHX8
Official Full Name: LIM homeobox 8provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16554 | LHX8 Knockout cell line (A549) | Human | LHX8 | 1:3~1:4 | Negative | Online Inquiry |
LHX8 Gene Knockout Cell Lines are specifically engineered cellular models that have had the LHX8 gene selectively disrupted. The LHX8 gene encodes a transcription factor that plays a crucial role in the development and function of various neuronal populations. By creating knockout cell lines, researchers can investigate the gene's contributions to neurodevelopmental processes and associated pathways more effectively.
The primary function of LHX8 Gene Knockout Cell Lines lies in their ability to facilitate the study of LHX8's impact on neuronal differentiation, synaptic formation, and overall neural circuit development. This is achieved through the absence of LHX8, allowing researchers to delineate its role and identify potential compensatory mechanisms activated in its absence. Additionally, these cell lines serve as a valuable tool for drug screening, providing insights into pharmacological interventions aimed at neurodevelopmental disorders linked to LHX8 dysregulation.
In research and clinical settings, LHX8 Gene Knockout Cell Lines are invaluable for advancing our understanding of LHX8-related pathologies, such as schizophrenia and autism spectrum disorders. Their scientific importance is underscored by their capacity to replicate certain neural characteristics observed in vivo, which enhances the translational potential of findings derived from their use.
What sets our LHX8 Gene Knockout Cell Lines apart from alternatives is our commitment to rigorous validation and characterization, ensuring that these models accurately reflect the absence of the target gene. Furthermore, our easy-to-use protocols and comprehensive support empower researchers to maximize their experimental outcomes.
For researchers and clinicians seeking to delve deeper into neurodevelopmental biology, our LHX8 Gene Knockout Cell Lines stand as a premier choice, delivering high-quality models that pave the way for innovative therapeutic approaches. With our extensive background in genetic engineering and cellular biology, we are dedicated to providing exceptional biological products that support groundbreaking research and improve clinical practices.
Please note that all services are for research use only. Not intended for any clinical use.
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