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LHX4 Knockout Cell Lines

Gene: LHX4

Official Full Name: LIM homeobox 4provided by HGNC

Gene Summary: This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23906 LHX4 Knockout cell line (HeLa) Human LHX4 1:3~1:6 Negative Online Inquiry
KO23907 LHX4 Knockout cell line (HCT 116) Human LHX4 1:2~1:4 Negative Online Inquiry
KO23908 LHX4 Knockout cell line (HEK293) Human LHX4 1:3~1:6 Negative Online Inquiry
KO23909 LHX4 Knockout cell line (A549) Human LHX4 1:3~1:4 Negative Online Inquiry

Background

LHX4 Gene Knockout Cell Lines are genetically modified cellular systems designed to selectively disable the LHX4 gene, which encodes a transcription factor critical for various developmental processes, particularly in the central nervous system and endocrine system. By knocking out this specific gene, researchers can investigate its role in lineage specification, neuronal differentiation, and molecular signaling pathways.

The primary mechanism of action involves the deletion of the LHX4 gene through advanced CRISPR/Cas9 technology, enabling precise gene editing with high efficiency and specificity. This allows for the in-depth analysis of the physiological and pathological implications of LHX4 deficiency in cellular models, leading to insights into related developmental disorders and neurodegenerative diseases.

Scientifically, LHX4 knockout cell lines hold immense importance in both basic and applied research contexts. They serve as powerful in vitro models for studying the gene's impact on neuronal development, synaptic formations, and hormone regulation in the pituitary gland. Their use in drug discovery and developmental biology can facilitate advancements in therapeutic strategies for conditions such as hypopituitarism and other neuroendocrine disorders.

These cell lines stand out due to their unprecedented reliability and reproducibility when compared to standard models. Unlike traditional knockout models, which can exhibit variable phenotypic expressions due to compensatory mechanisms, LHX4 Gene Knockout Cell Lines provide a consistent and targeted analysis of gene function. This reliability significantly enhances experimental outcomes, making them an invaluable tool for researchers.

For researchers and clinicians alike, these cell lines offer a unique opportunity to delve into gene function with a clarity that can accelerate findings in genetics and molecular biology. The ability to manipulate and study this transcription factor in a controlled environment can catalyze significant breakthroughs in understanding complex biological systems.

Our company, with years of expertise in genetic engineering and cellular systems, is dedicated to empowering researchers through innovative biological products such as LHX4 Gene Knockout Cell Lines. We continuously strive to provide tools that facilitate groundbreaking discoveries and enhance scientific knowledge across various disciplines.

Please note that all services are for research use only. Not intended for any clinical use.

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