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LGMN Knockout Cell Lines

Gene: LGMN

Official Full Name: legumainprovided by HGNC

Gene Summary: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35880 LGMN Knockout cell line (HeLa) Human LGMN 1:3~1:6 Negative Online Inquiry
KO35881 LGMN Knockout cell line (HCT 116) Human LGMN 1:2~1:4 Negative Online Inquiry
KO35882 LGMN Knockout cell line (HEK293) Human LGMN 1:3~1:6 Negative Online Inquiry
KO35883 LGMN Knockout cell line (A549) Human LGMN 1:3~1:4 Negative Online Inquiry

Background

LGMN Gene Knockout Cell Lines are meticulously engineered cellular models that facilitate the study of the legumain (LGMN) gene, a vital component in various physiological and pathological processes, including protein degradation and immune response modulation. These knockout cell lines enable researchers to investigate gene function by providing a knockout variant where the LGMN gene is inactivated, thereby eliminating its protein expression. This allows for precise examination of the consequences of LGMN deficiency on cellular behavior and biochemical pathways.

The key functions of LGMN Gene Knockout Cell Lines lie in their ability to elucidate the role of legumain in cellular processes such as apoptosis, tumor progression, and the inflammation response. By observing the differences in phenotypic traits and molecular pathways between wild-type and knockout cells, researchers can unravel complex mechanisms underlying various diseases. Such models are instrumental in drug discovery and development, particularly in identifying potential therapeutic targets and assessing drug efficacy.

From a scientific perspective, these knockout cell lines hold great importance in both research and clinical settings. They provide a robust platform for studying diseases such as cancer, where LGMN expression may be altered, as well as for understanding immune dysfunctions. This makes them invaluable for researchers focused on oncology, immunology, and therapeutic development.

Compared to alternative models, LGMN Gene Knockout Cell Lines offer significant advantages in specificity and precision. While other knockouts might propagate off-target effects, our lines are designed to ensure that LGMN is the primary gene affected. Moreover, they possess high reproducibility in experimental setups, enabling consistent and reliable results.

For researchers and clinicians seeking to deepen their understanding of the legumain gene's impact or to explore novel therapeutic interventions, these cell lines present an exceptional research tool. The ability to manipulate gene expression intricately aligns with modern precision medicine approaches, further enhancing their value.

Our company boasts extensive expertise in developing high-quality biological models tailored to the needs of the scientific community. With a commitment to innovation and excellence, we provide researchers with tools that not only advance their studies but also contribute to breakthroughs in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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