Gene: LDLRAD4
Official Full Name: low density lipoprotein receptor class A domain containing 4provided by HGNC
Gene Summary: Enables R-SMAD binding activity. Involved in negative regulation of cell migration; negative regulation of epithelial to mesenchymal transition; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in early endosome membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38723 | LDLRAD4 Knockout cell line (HeLa) | Human | LDLRAD4 | 1:3~1:6 | Negative | Online Inquiry |
KO38724 | LDLRAD4 Knockout cell line (HEK293) | Human | LDLRAD4 | 1:3~1:6 | Negative | Online Inquiry |
KO38725 | LDLRAD4 Knockout cell line (A549) | Human | LDLRAD4 | 1:3~1:4 | Negative | Online Inquiry |
LDLRAD4 Gene Knockout Cell Lines are specialized cellular models engineered to delete the LDLRAD4 gene, which is implicated in various biological processes, including lipid metabolism and cellular signaling. This product provides researchers with valuable tools to investigate the functional consequences of LDLRAD4 gene loss, enhancing our understanding of its role in both health and disease.
The primary function of these knockout cell lines lies in their ability to mimic the loss of gene function, enabling studies related to dyslipidemia, cardiovascular diseases, and metabolic disorders. Mechanistically, the removal of the LDLRAD4 gene allows researchers to examine the downstream effects on pathways related to low-density lipoprotein (LDL) uptake and how regulatory mechanisms may be altered in diseases. By comparing these knockout cells with wild-type counterparts, researchers can elucidate the specific contributions of LDLRAD4 in various biological contexts.
The scientific importance of LDLRAD4 Gene Knockout Cell Lines is manifold, with applications spanning basic research, drug discovery, and the development of therapeutic strategies. They serve as crucial models for understanding the molecular underpinnings of diseases associated with lipid metabolism, such as hypercholesterolemia and atherosclerosis, as well as for testing potential interventions.
Advantages of this product include a reliable and reproducible model that reflects the physiological relevance of gene knockout approaches. By using these specialized cell lines, researchers can achieve more precise insights compared to alternative methods, such as pharmacological inhibition or transient gene silencing, which may not fully recapitulate the complete loss of function effects.
For researchers and clinicians eager to advance their understanding of lipid metabolic pathways and explore novel therapeutic options, LDLRAD4 Gene Knockout Cell Lines represent an invaluable resource. With over [insert relevant years] years of expertise in providing high-quality biological products, our company is committed to supporting the scientific community with advanced tools that facilitate groundbreaking research and discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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