LAMC3 Knockout Cell Lines

Gene: LAMC3

Official Full Name: laminin subunit gamma 3provided by HGNC

Gene Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number	Product Name	Species	Gene	Passage ratio	Mycoplasma testing	Price
KO10240	LAMC3 Knockout cell line (HeLa)	Human	LAMC3	1:3~1:6	Negative	Online Inquiry
KO10241	LAMC3 Knockout cell line (HCT 116)	Human	LAMC3	1:2~1:4	Negative	Online Inquiry
KO10242	LAMC3 Knockout cell line (HEK293)	Human	LAMC3	1:3~1:6	Negative	Online Inquiry
KO10243	LAMC3 Knockout cell line (A549)	Human	LAMC3	1:3~1:4	Negative	Online Inquiry

Background

LAMC3 Gene Knockout Cell Lines are specialized cultured cells that have been genetically modified to disrupt the expression of the LAMC3 gene, which encodes a critical component of the laminin protein family. Laminins play an essential role in cellular adhesion, differentiation, migration, and the maintenance of the extracellular matrix. By utilizing CRISPR-Cas9 or other gene-editing technologies to achieve a complete knockout of the LAMC3 gene, these cell lines enable researchers to investigate the functional significance of LAMC3 in various biological processes and disease states.

The key function of LAMC3 Gene Knockout Cell Lines lies in their ability to serve as models for studying the implications of LAMC3 deficiency in vitro. These models allow for the exploration of cellular pathways involved in tumor progression, tissue regeneration, and neurodevelopment, as well as various pathologies linked to connective tissue disorders. The absence of LAMC3 generates a unique platform for examining how this loss affects cellular interactions with the extracellular matrix and influences cellular behavior and signaling pathways.

From a scientific perspective, LAMC3 Gene Knockout Cell Lines are invaluable in both research and clinical applications. They facilitate the understanding of complex diseases, including cancer and neurological conditions, for which LAMC3 may serve as a potential therapeutic target. Additionally, these cell lines support the development of new treatment strategies and diagnostic tools.

When compared to traditional cell line models, such as those that rely on siRNA or shRNA for transient gene silencing, LAMC3 Gene Knockout Cell Lines offer a more stable and long-lasting solution, allowing for the generation of more reproducible and reliable experimental data. This stability enhances the overall efficiency of research, saving valuable time and resources.

Researchers and clinicians seeking to advance their understanding of the roles of laminin proteins in health and disease will find LAMC3 Gene Knockout Cell Lines to be a crucial addition to their toolkit. The availability of these specialized cell models underscores the commitment of our company to provide cutting-edge biological products that empower the scientific community in their quest for innovation and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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