Gene: KRT83
Official Full Name: keratin 83provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36866 | KRT83 Knockout cell line (A549) | Human | KRT83 | 1:3~1:4 | Negative | Online Inquiry |
KRT83 Gene Knockout Cell Lines are advanced cellular models that have been genetically engineered to feature a targeted deletion of the KRT83 gene, a critical component of the keratin family responsible for maintaining the structural integrity and function of epithelial tissues. These cell lines serve as invaluable tools for studying the role of KRT83 in various biological processes, including cell differentiation, proliferation, and response to external stimuli, particularly under conditions associated with skin and other epithelial disorders.
The primary mechanism by which KRT83 Knockout Cell Lines exert their value lies in their ability to enable researchers to elucidate the gene's functional role. By comparing the knockout cells with wild-type counterparts, scientists can explore phenotype alterations, changes in signaling pathways, and the impact on cellular stress responses. This capability provides profound insights into keratinocyte biology and its implications in conditions such as psoriasis, wound healing, and certain cancers.
The scientific importance of KRT83 Knockout Cell Lines is underscored by their applications in both research and clinical settings. They are essential for drug screening, gene therapy development, and understanding the molecular basis of skin diseases. Furthermore, these models facilitate the identification of potential therapeutic targets, making significant contributions to translational medicine.
In comparison to conventional cell lines, KRT83 Knockout Cell Lines present unique advantages, such as specificity of gene disruption and the ability to model diseases more accurately. They provide robustness in experimental reproducibility and allow detailed investigations into gene function without the confounding variables inherent in unaltered systems.
For researchers and clinicians focused on dermatological conditions, these cell lines represent a powerful resource, fostering innovation in therapeutic strategies and advancing our understanding of skin biology. By integrating cutting-edge genetic engineering with superior cellular models, our company offers comprehensive support to the scientific community, ensuring that our KRT83 Gene Knockout Cell Lines are not only high quality but also pivotal in addressing the challenges of contemporary biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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