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KREMEN1 Knockout Cell Lines

Gene: KREMEN1

Official Full Name: kringle containing transmembrane protein 1provided by HGNC

Gene Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Mutations in this gene result in ectodermal dysplasia. This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2. [provided by RefSeq, Nov 2021]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00796 KREMEN1 Knockout cell line(293T) Human KREMEN1 1:3~1:6 Negative Online Inquiry
KO00949 KREMEN1 Knockout cell line(NCI-H1299) Human KREMEN1 1:2~1:3 Negative Online Inquiry
KO00956 KREMEN1 Knockout cell line(RKO) Human KREMEN1 1:2~1:4 Negative Online Inquiry
KO16628 KREMEN1 Knockout cell line (HCT 116) Human KREMEN1 1:2~1:4 Negative Online Inquiry
KO16629 KREMEN1 Knockout cell line (HEK293) Human KREMEN1 1:3~1:6 Negative Online Inquiry
KO16630 KREMEN1 Knockout cell line (A549) Human KREMEN1 1:3~1:4 Negative Online Inquiry

Background

KREMEN1 Gene Knockout Cell Lines are precisely engineered cellular models designed to facilitate extensive investigations into the function and therapeutic potential of the KREMEN1 gene. The KREMEN1 gene is significant due to its critical role in regulating Wnt signaling pathways, which are crucial for various cellular processes, including development, tissue homeostasis, and cancer progression. By utilizing CRISPR-Cas9 technology, these knockout cell lines eliminate the expression of KREMEN1, allowing researchers to explore its impact on cellular behaviors and signaling mechanisms more profoundly.

The primary function of the KREMEN1 Gene Knockout Cell Lines is to provide a controlled environment for dissecting the biological consequences of KREMEN1 loss. In these cell lines, researchers can observe alterations in cell proliferation, differentiation, and migration, as well as changes in Wnt pathway activity. This model is invaluable for elucidating the gene's role in oncogenesis and its potential as a therapeutic target.

In a research setting, KREMEN1 Gene Knockout Cell Lines hold significant importance as they enable scientists to identify novel biomarkers and therapeutic strategies for conditions linked to aberrant Wnt signaling, such as colorectal cancer, neurodegenerative diseases, and metabolic disorders. Clinically, these lines can be pivotal in developing targeted therapies that could enhance patient outcomes.

What sets KREMEN1 Gene Knockout Cell Lines apart from alternative models is their precision and reproducibility, enabling direct comparisons and validations of experimental results. Moreover, these cell lines are fully characterized and validated for consistent performance, ensuring reliability in research outcomes.

The unique ability to manipulate and examine the consequences of knocking out the KREMEN1 gene provides researchers and clinicians with a powerful tool for advancing biomedical knowledge and therapeutic interventions. This product epitomizes the sophistication of modern genetic engineering while offering an accessible route for exploring complex biological pathways.

Our company brings years of expertise in biotechnology and cellular biology, committed to providing high-quality, validated research tools that empower scientists worldwide to drive innovation in their fields.

Please note that all services are for research use only. Not intended for any clinical use.

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