Gene: KPNA2
Official Full Name: karyopherin subunit alpha 2provided by HGNC
Gene Summary: The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03367 | KPNA2 Knockout cell line (HeLa) | Human | KPNA2 | 1:3~1:6 | Negative | Online Inquiry |
KO03368 | KPNA2 Knockout cell line (HCT 116) | Human | KPNA2 | 1:2~1:4 | Negative | Online Inquiry |
KO03369 | KPNA2 Knockout cell line (HEK293) | Human | KPNA2 | 1:3~1:6 | Negative | Online Inquiry |
KO03370 | KPNA2 Knockout cell line (A549) | Human | KPNA2 | 1:3~1:4 | Negative | Online Inquiry |
KPNA2 Gene Knockout Cell Lines are genetically modified cell lines designed specifically to facilitate the study of the KPNA2 gene, which encodes a nuclear transport receptor that plays a critical role in transporting proteins into the nucleus. These cell lines have been engineered to exhibit a complete knockout of the KPNA2 gene, effectively eliminating the expression of its protein product. This modification allows researchers to investigate the functional consequences of KPNA2 loss and provides invaluable insights into its role in cellular processes such as nuclear transport, gene expression regulation, and cellular signaling pathways.
The key function of KPNA2 Gene Knockout Cell Lines lies in their ability to serve as a model for understanding the implications of KPNA2 dysregulation, which has been implicated in various diseased states, including cancer and neurological disorders. By utilizing these knockout cell lines, researchers can conduct comparative studies on gene expression profiles, protein localization, and cellular responses to stimuli, uncovering potential pathways that could be targeted for therapeutic interventions.
From a scientific standpoint, these cell lines are crucial for advancing knowledge in molecular biology and genetics. They provide a powerful tool for drug development and biomarker discovery, offering a platform for screening compounds that may impact KPNA2-related pathways. Furthermore, their applications extend to academic research, pharmaceutical development, and biotechnological innovations, making them integral to a variety of research and clinical settings.
What sets the KPNA2 Gene Knockout Cell Lines apart from alternative models is their specificity and the reliability of gene editing techniques used in their creation. The precise knockout ensures that any observed effects can be directly attributed to the absence of KPNA2, providing clarity in experimental outcomes. Additionally, these cell lines are compatible with standard culture protocols and can be readily adapted to high-throughput screening applications, significantly enhancing their usability.
For researchers and clinicians seeking to explore the functions of KPNA2 in disease mechanisms or therapeutic insights, these knockout cell lines present unparalleled value. Leveraging state-of-the-art genetic engineering methodologies, our company is committed to providing high-quality biological products that empower scientific exploration and innovation. By choosing KPI-validated cell lines for your research, you are investing in a resource that not only accelerates your work but also contributes to the evolution of personalized medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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