Gene: KLHL3
Official Full Name: kelch like family member 3provided by HGNC
Gene Summary: This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28189 | KLHL3 Knockout cell line (HEK293) | Human | KLHL3 | 1:3~1:6 | Negative | Online Inquiry |
KLHL3 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to disable the KLHL3 gene, which encodes a key protein involved in various cellular processes such as ion transport and regulatory mechanisms in cell signaling. By knocking out the KLHL3 gene, researchers can effectively study the resultant phenotypic changes, offering insights into its role in vital physiological functions, particularly those linked to kidney function and hypertension-related diseases.
The primary mechanism of action involves CRISPR-Cas9 technology, which allows for precise editing of the genome. This targeted approach enables scientists to observe the effects of KLHL3 loss in cellular pathways and stress responses, providing a powerful tool for understanding the gene's biological relevance. These knockout cell lines facilitate the study of ion homeostasis, cellular response to hormonal signaling, and the implications of KLHL3 mutations in disease models, making them invaluable for both basic and applied research.
In the context of scientific and clinical applications, KLHL3 Gene Knockout Cell Lines are pivotal in investigating hypertension, kidney diseases, and other related metabolic disorders. By elucidating the biological roles of KLHL3, researchers can uncover potential therapeutic targets, paving the way for innovative treatment strategies.
One of the significant advantages of our KLHL3 Gene Knockout Cell Lines is their high specificity and reliability when compared to existing alternatives. Our products are validated for consistent performance across various experimental conditions, ensuring reproducibility in research findings—an essential factor in advancing scientific knowledge. Moreover, our cell lines come with comprehensive support and characterization data, simplifying the integration into ongoing research projects.
For researchers and clinicians alike, the KLHL3 Gene Knockout Cell Lines represent a unique opportunity to deepen their understanding of genetic contributions to disease. By leveraging our expertise in molecular biology and genetic engineering, we ensure that our products embody the latest advancements in the field, providing researchers with cutting-edge tools to drive their studies forward.
Please note that all services are for research use only. Not intended for any clinical use.
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