Gene: KLHL25
Official Full Name: kelch like family member 25provided by HGNC
Gene Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; regulation of fatty acid metabolic process; and ubiquitin-dependent protein catabolic process. Located in cytoplasm. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16663 | KLHL25 Knockout cell line (HeLa) | Human | KLHL25 | 1:3~1:6 | Negative | Online Inquiry |
KO16664 | KLHL25 Knockout cell line (HCT 116) | Human | KLHL25 | 1:2~1:4 | Negative | Online Inquiry |
KO16665 | KLHL25 Knockout cell line (HEK293) | Human | KLHL25 | 1:3~1:6 | Negative | Online Inquiry |
KO16666 | KLHL25 Knockout cell line (A549) | Human | KLHL25 | 1:3~1:4 | Negative | Online Inquiry |
KLHL25 Gene Knockout Cell Lines are genetically modified cell cultures designed to facilitate the functional analysis of the KLHL25 gene, a protein-coding gene implicated in various cellular processes, including protein degradation and stress response. These knockout cell lines have been engineered to lack the expression of the KLHL25 gene, thereby enabling researchers to investigate the role of this gene in cellular physiology and pathophysiology effectively.
The primary mechanism of action of the KLHL25 knockout involves the disruption of the gene's coding sequence, which prevents the synthesis of the KLHL25 protein. This gene typically associates with Cullin-RING E3 ubiquitin ligase complexes, so its absence can significantly alter ubiquitination pathways and protein turnover within the cell. Consequently, understanding the consequences of KLHL25 depletion provides critical insights into its functional role in cellular homeostasis and disease states, such as cancer and neurodegenerative disorders.
The scientific significance of KLHL25 Gene Knockout Cell Lines extends into both research and clinical settings. Researchers utilize these cell lines to study gene function, elucidate molecular mechanisms of disease, and explore potential therapeutic targets. The availability of these knockout models also accelerates the development of innovative treatments and diagnostic tools by allowing for robust preclinical testing.
Distinct from standard knockdown techniques, which may retain residual gene function, our KLHL25 Gene Knockout Cell Lines provide a complete ablation of gene activity, offering unmatched specificity and reliability in experimental outcomes. This full knockout approach allows for an unequivocal assessment of the gene's role in various biological contexts.
For researchers and clinicians alike, the value of KLHL25 Gene Knockout Cell Lines lies in their ability to yield reproducible data that can lead to groundbreaking discoveries in molecular biology and therapeutic development. They provide indispensable models for investigating the ramifications of KLHL25 deletion in a controlled environment.
Our company combines extensive experience in biotechnology with a commitment to delivering high-quality, validated research products. By choosing our KLHL25 Gene Knockout Cell Lines, you gain access to a sophisticated tool engineered to enhance your research endeavors and facilitate advancements in understanding gene function and disease mechanisms.
Please note that all services are for research use only. Not intended for any clinical use.
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