Gene: KIFAP3
Official Full Name: kinesin associated protein 3provided by HGNC
Gene Summary: The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30123 | KIFAP3 Knockout cell line (HeLa) | Human | KIFAP3 | 1:3~1:6 | Negative | Online Inquiry |
KO30124 | KIFAP3 Knockout cell line (HCT 116) | Human | KIFAP3 | 1:2~1:4 | Negative | Online Inquiry |
KO30125 | KIFAP3 Knockout cell line (HEK293) | Human | KIFAP3 | 1:3~1:6 | Negative | Online Inquiry |
KO30126 | KIFAP3 Knockout cell line (A549) | Human | KIFAP3 | 1:3~1:4 | Negative | Online Inquiry |
KIFAP3 Gene Knockout Cell Lines are genetically modified cell lines that selectively disrupt the expression of the KIFAP3 gene, which encodes a member of the kinesin family of motor proteins responsible for intracellular transport. These knockout cell lines serve as powerful tools for researchers aiming to elucidate the cellular and molecular functions of KIFAP3, including its role in mitosis, organelle movement, and cell signaling pathways. By employing CRISPR-Cas9 or other gene editing technologies, these cell lines effectively disable the KIFAP3 protein, allowing scientists to study the consequences of its absence in a controlled environment.
The primary function of KIFAP3 is that of a motor protein, facilitating the movement of cellular components along microtubules. By utilizing these knockout cell lines, researchers can investigate alterations in cellular behavior, changes in intracellular transport mechanisms, and the subsequent effects on cell viability and proliferation. In addition to fundamental biological research, these cell lines have potential applications in drug discovery, where understanding the molecular targets and pathways influenced by KIFAP3 may lead to novel therapeutic strategies.
One of the key advantages of utilizing KIFAP3 Gene Knockout Cell Lines over traditional methods is the precision and efficiency of gene targeting, which allows for a cleaner phenotype without the off-target effects often associated with earlier gene manipulation techniques. They simplify experimental design, providing a clearer model for studying specific gene functions and their implications in disease. This specificity is particularly crucial in clinical settings and therapeutic research, where understanding the role of genes within complex networks remains a significant challenge.
Researchers and clinicians can greatly benefit from this product by obtaining reliable models to assess the functional role of KIFAP3, thus advancing their work in cancer research, neurodegenerative diseases, and cellular biology. The availability of these knockout cell lines accelerates the pace of discovery and innovation in the life sciences.
At [Your Company Name], we pride ourselves on our commitment to providing cutting-edge biological tools that empower researchers and clinicians to push the boundaries of scientific knowledge. With a robust portfolio of gene editing products and services, we strive to enhance the quality and efficacy of research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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