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KIF5A Knockout Cell Lines

Gene: KIF5A

Official Full Name: kinesin family member 5Aprovided by HGNC

Gene Summary: This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36963 KIF5A Knockout cell line (HCT 116) Human KIF5A 1:2~1:4 Negative Online Inquiry
KO36964 KIF5A Knockout cell line (HEK293) Human KIF5A 1:3~1:6 Negative Online Inquiry
KO36965 KIF5A Knockout cell line (A549) Human KIF5A 1:3~1:4 Negative Online Inquiry

Background

KIF5A Gene Knockout Cell Lines are specialized cellular models engineered to lack expression of the KIF5A gene, which encodes a motor protein involved in the transport of cellular cargo along microtubules. These cell lines facilitate extensive investigation into the role of KIF5A in various cellular processes, including intracellular transport, cell division, and neuronal development. By employing CRISPR-Cas9 or similar genome editing technologies, these cell lines provide a toolset for dissecting the molecular mechanisms underlying significant physiological and pathological phenomena.

The primary function of KIF5A encompasses the transport of vital organelles and signaling molecules within the cytoplasm, making it crucial for maintaining cellular homeostasis. Disruption of KIF5A function has been implicated in neurological disorders, highlighting the importance of these knockout models in research. Utilizing KIF5A knockout cell lines enables scientists to elucidate gene function and regulatory networks, paving the way for potential therapeutic interventions in diseases linked to KIF5A dysregulation.

Compared to standard wild-type cell lines, KIF5A knockout cell lines offer unparalleled advantages in specificity and relevance, allowing researchers to explore the consequences of KIF5A loss-of-function without confounding factors. These cell lines can be easily integrated into various experimental paradigms, from biochemical assays to high-throughput screening, enhancing the robustness of experimental data.

For researchers and clinicians, the ability to manipulate and study genes involved in critical cellular processes is invaluable. KIF5A knockout cell lines empower studies that can lead to novel insights in neurobiology and potential methodologies for drug discovery.

Our company is dedicated to providing high-quality biological products, including superior gene-editing tools and established cellular models. With a commitment to advancing scientific research, we ensure that our KIF5A Gene Knockout Cell Lines meet rigorous standards, enabling researchers to push the boundaries of discovery in their fields.

Please note that all services are for research use only. Not intended for any clinical use.

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