Gene: KIAA0586
Official Full Name: KIAA0586provided by HGNC
Gene Summary: This gene encodes a conserved centrosomal protein that functions in ciliogenesis and responds to hedgehog signaling. Mutations in this gene causes Joubert syndrome 23. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Aug 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32751 | KIAA0586 Knockout cell line (HeLa) | Human | KIAA0586 | 1:3~1:6 | Negative | Online Inquiry |
KO32752 | KIAA0586 Knockout cell line (HCT 116) | Human | KIAA0586 | 1:2~1:4 | Negative | Online Inquiry |
KO32753 | KIAA0586 Knockout cell line (HEK293) | Human | KIAA0586 | 1:3~1:6 | Negative | Online Inquiry |
KO32754 | KIAA0586 Knockout cell line (A549) | Human | KIAA0586 | 1:3~1:4 | Negative | Online Inquiry |
KIAA0586 Gene Knockout Cell Lines are a sophisticated tool designed to study the functional biology of the KIAA0586 gene, which encodes a protein believed to play a significant role in cellular processes related to bone homeostasis and potential pathway regulation in various diseases. By utilizing CRISPR-Cas9 technology, these cell lines enable the precise elimination of KIAA0586 expression, facilitating a deeper understanding of the gene’s functions and its implications in pathophysiology.
The mechanism of action hinges upon the targeted cleavage of the KIAA0586 gene, which leads to the generation of knockout phenotypes that researchers can analyze for altered cellular behaviors, signaling pathways, and interactions. This allows for the dissection of the gene's involvement in critical cellular processes such as proliferation, differentiation, and apoptosis. Such insights are invaluable for elucidating disease mechanisms, particularly in contexts like cancer research and osteoporosis.
The scientific importance of KIAA0586 Gene Knockout Cell Lines extends into both research and clinical settings. They are essential for investigators focused on gene function and pathology, as they provide a clear model system for testing hypotheses related to gene activity, therapeutic interventions, and biomarker discovery. When compared to other gene-editing methods, the specificity and efficiency yielded by CRISPR technology in these cell lines confer an advantage, reducing off-target effects and resulting in more reliable data.
For researchers and clinicians alike, KIAA0586 Gene Knockout Cell Lines offer an invaluable resource for advancing our understanding of genetic contributions to disease and potential treatments. Their ability to closely model the loss of gene function in vitro enhances their value as a tool for drug discovery and disease modeling.
Our company specializes in the development of advanced biological products, combining rigorous scientific research with cutting-edge technological applications. With a commitment to quality and innovation, we strive to provide researchers with the tools necessary to address complex biological questions and drive forward the frontiers of science.
Please note that all services are for research use only. Not intended for any clinical use.
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