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KDM2A Knockout Cell Lines

Gene: KDM2A

Official Full Name: lysine demethylase 2Aprovided by HGNC

Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04716 KDM2A Knockout cell line (HeLa) Human KDM2A 1:3~1:6 Negative Online Inquiry
KO04717 KDM2A Knockout cell line (HCT 116) Human KDM2A 1:2~1:4 Negative Online Inquiry
KO04718 KDM2A Knockout cell line (HEK293) Human KDM2A 1:3~1:6 Negative Online Inquiry
KO04719 KDM2A Knockout cell line (A549) Human KDM2A 1:3~1:4 Negative Online Inquiry

Background

KDM2A Gene Knockout Cell Lines are specially engineered cellular models that have undergone targeted genome editing to eliminate the expression of the KDM2A gene. KDM2A encodes a lysine demethylase that plays a critical role in epigenetic regulation, influencing both chromatin structure and gene expression. By creating KDM2A knockout cell lines, researchers can investigate the gene's functions and its contributions to various biological pathways, particularly those involved in cancer progression and stem cell maintenance.

These cell lines enable a detailed exploration of the molecular mechanisms by which KDM2A influences cellular processes such as proliferation, differentiation, and response to environmental cues. The deletion of the KDM2A gene allows researchers to observe phenotypic changes directly attributable to its absence, providing insights into its role as a potential therapeutic target. Additionally, these cell lines are invaluable tools in drug discovery and development, facilitating the screening of pharmacological agents that might modulate KDM2A activity.

Compared to similar offerings, KDM2A Gene Knockout Cell Lines stand out for their high specificity and efficiency achieved through precise genome editing technologies, such as CRISPR/Cas9. This ensures that researchers are working with reliable models that accurately reflect the biological impacts of KDM2A loss. Furthermore, these cell lines are validated for consistent performance across various experimental platforms, making them an essential asset for basic and applied research.

For scientists and clinicians focused on unraveling the complexities of epigenetic regulation and its implications in health and disease, KDM2A Gene Knockout Cell Lines offer unmatched convenience and precision. By utilizing these specialized tools, users can accelerate their research findings and potentially translate those discoveries into innovative clinical applications.

Our company, committed to advancing biomedical research, has a proven track record in developing high-quality biological products. We leverage cutting-edge technology and rigorous validation processes to provide researchers with the resources needed to drive scientific progress.

Please note that all services are for research use only. Not intended for any clinical use.

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