Gene: KCNG3
Official Full Name: potassium voltage-gated channel modifier subfamily G member 3provided by HGNC
Gene Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16830 | KCNG3 Knockout cell line (HeLa) | Human | KCNG3 | 1:3~1:6 | Negative | Online Inquiry |
KO16831 | KCNG3 Knockout cell line (HCT 116) | Human | KCNG3 | 1:2~1:4 | Negative | Online Inquiry |
KO16832 | KCNG3 Knockout cell line (HEK293) | Human | KCNG3 | 1:3~1:6 | Negative | Online Inquiry |
KO16833 | KCNG3 Knockout cell line (A549) | Human | KCNG3 | 1:3~1:4 | Negative | Online Inquiry |
KCNG3 Gene Knockout Cell Lines are specialized biological tools that have been genetically engineered to lack the expression of the KCNG3 gene, which encodes for the potassium channel protein K+ 2.1. These cell lines provide a heterologous platform for investigating the physiological role of KCNG3 in various cellular processes, including excitability, neuronal signaling, and cardiovascular functions. By specifically disrupting the expression of the KCNG3 gene, researchers can elucidate the consequences of its absence on ion conductance and other cellular responses.
The key functions of KCNG3 Gene Knockout Cell Lines center around their ability to provide a clear model for studying the ramifications of K+ channel deficits. Upon knocking out this gene, alterations in cellular membrane potential and response to depolarization events can be distinctly observed. This direct approach allows for a more accurate investigation into the cellular mechanisms underlying various pathophysiological conditions, including epilepsy, cardiac arrhythmias, and other neurological disorders.
In research and clinical settings, these cell lines hold significant scientific importance as they facilitate the understanding of potassium's role in cellular excitability and provide a valuable system for drug screening and electrophysiological studies. The KCNG3 Gene Knockout Cell Lines have proven invaluable for pharmaceutical companies and academic institutions investigating therapeutic strategies targeting ion channels.
Compared to other cell lines or gene editing techniques, our KCNG3 Gene Knockout Cell Lines offer distinct advantages, including enhanced specificity and reproducibility. Our product provides a stable and consistent genetic background, reducing variability inherent in other models. Furthermore, the availability of these knockout models streamlines experimental design and accelerates discovery, making it an indispensable asset for researchers.
Overall, the KCNG3 Gene Knockout Cell Lines represent a vital resource for anyone focused on ion channel research, cardiovascular health, or neurophysiology. By leveraging our advanced gene editing technologies and high-quality cell culture systems, our company stands at the forefront of biological research products, delivering scientifically robust solutions tailored to the precise needs of our users.
Please note that all services are for research use only. Not intended for any clinical use.
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