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KAT7 Knockout Cell Lines

Gene: KAT7

Official Full Name: lysine acetyltransferase 7provided by HGNC

Gene Summary: The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01475 KAT7 Knockout cell line(Hep G2) Human KAT7 1:2~1:4 Negative Online Inquiry
KO16842 KAT7 Knockout cell line (HeLa) Human KAT7 1:3~1:6 Negative Online Inquiry
KO16843 KAT7 Knockout cell line (HCT 116) Human KAT7 1:2~1:4 Negative Online Inquiry
KO16844 KAT7 Knockout cell line (HEK293) Human KAT7 1:3~1:6 Negative Online Inquiry
KO16845 KAT7 Knockout cell line (A549) Human KAT7 1:3~1:4 Negative Online Inquiry

Background

KAT7 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to elucidate the function of the KAT7 gene, which encodes a lysine acetyltransferase implicated in various biological processes such as transcriptional regulation, DNA damage repair, and cancer biology. These cell lines facilitate the comprehensive investigation of KAT7's contribution to cellular homeostasis and its potential role in oncogenesis.

Mechanistically, the knockout of the KAT7 gene results in an absence of the acetylation marks typically placed on target histones and non-histone substrates, thereby disrupting downstream signaling pathways and altering gene expression profiles. This loss of KAT7 activity allows researchers to study its effects on cellular differentiation, response to stress, and tumorigenic potential, providing insights into how manipulating acetylation states can influence cellular behavior.

From a scientific perspective, KAT7 Gene Knockout Cell Lines serve as vital tools in molecular and cellular biology, offering applications in drug development, cancer research, and functional genomics. Researchers can leverage these models to screen for novel therapeutics that restore normal cellular functions lost due to KAT7 dysregulation, contributing substantially to our understanding of complex diseases.

The advantages of our KAT7 Gene Knockout Cell Lines lie in their high efficiency and reliability compared to conventional methods. Unlike siRNA approaches, which only temporarily inhibit gene function, these stable knockout lines provide a consistent and reproducible platform for long-term studies. Furthermore, our cell lines are rigorously validated and characterized, which enhances experimental robustness.

For researchers and clinicians invested in deciphering the intricacies of gene function and cellular pathways, our KAT7 Gene Knockout Cell Lines offer unparalleled value. By utilizing these well-established models, you can expedite your research endeavors, yielding results that may inform therapeutic strategies and improve patient outcomes.

At [Your Company Name], we pride ourselves on our extensive expertise in providing high-quality genetic tools and resources tailored to the needs of modern biomedical research. Our commitment to innovation and precision ensures our products meet the highest standards, empowering you to advance your research effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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