Gene: KAT2B
Official Full Name: lysine acetyltransferase 2Bprovided by HGNC
Gene Summary: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11382 | KAT2B Knockout cell line (HeLa) | Human | KAT2B | 1:3~1:6 | Negative | Online Inquiry |
KO11383 | KAT2B Knockout cell line (HCT 116) | Human | KAT2B | 1:2~1:4 | Negative | Online Inquiry |
KO11384 | KAT2B Knockout cell line (HEK293) | Human | KAT2B | 1:3~1:6 | Negative | Online Inquiry |
KO11385 | KAT2B Knockout cell line (A549) | Human | KAT2B | 1:3~1:4 | Negative | Online Inquiry |
KAT2B Gene Knockout Cell Lines are advanced biological tools designed to facilitate the study of the KAT2B gene, which encodes a histone acetyltransferase playing a crucial role in gene regulation and cellular processes. These knockout cell lines are engineered to completely disrupt the expression of the KAT2B gene, allowing researchers to investigate the gene's function and its implications in various biological pathways and diseases.
The primary function of KAT2B knockout cell lines revolves around their ability to elucidate the cellular mechanisms governed by KAT2B through functional assays. By removing the KAT2B gene, researchers can observe phenotypic changes and study the downstream effects on gene expression, metabolism, and cellular signaling. This invaluable information aids in understanding the role of KAT2B in contexts such as cancer biology, neurodegenerative disorders, and metabolic diseases.
In a research or clinical setting, these knockout cell lines are crucial for investigating the molecular mechanisms underlying diseases that involve dysregulation of acetylation processes, enabling the development of targeted therapies. Their use can enhance the discovery of biomarkers or therapeutic targets, thereby accelerating the translational science needed for effective medical interventions.
Compared to alternative models, KAT2B Gene Knockout Cell Lines offer specific advantages, including high reproducibility and the ability to manipulate genetic backgrounds for diverse experimental needs. The specificity of gene disruption ensures clarity in observed phenotypes, which is often not achievable with partial inhibitions or pharmacological agents.
For researchers and clinicians focused on cutting-edge investigations in gene function and regulation, KAT2B Gene Knockout Cell Lines represent an invaluable asset. By utilizing this product, they can expand their insights into epigenetic regulation and develop innovative strategies in gene therapy or precision medicine.
At our company, we pride ourselves on delivering high-quality, scientifically validated biological products engineered by a team of experts committed to advancing research and therapeutic development. With our robust offerings, researchers can confidently push the boundaries of knowledge in their respective fields.
Please note that all services are for research use only. Not intended for any clinical use.
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