Gene: JOSD2
Official Full Name: Josephin domain containing 2provided by HGNC
Gene Summary: This gene encodes a protein containing a Josephin domain. Josephin domain-containing proteins are deubiquitinating enzymes which catalyze the hydrolysis of the bond between the C-terminal glycine of the ubiquitin peptide and protein substrates. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27444 | JOSD2 Knockout cell line (HeLa) | Human | JOSD2 | 1:3~1:6 | Negative | Online Inquiry |
KO27445 | JOSD2 Knockout cell line (HCT 116) | Human | JOSD2 | 1:2~1:4 | Negative | Online Inquiry |
KO27446 | JOSD2 Knockout cell line (HEK293) | Human | JOSD2 | 1:3~1:6 | Negative | Online Inquiry |
KO27447 | JOSD2 Knockout cell line (A549) | Human | JOSD2 | 1:3~1:4 | Negative | Online Inquiry |
JOSD2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the JOSD2 gene, providing researchers with a powerful tool for studying gene function, cellular processes, and disease mechanisms. By utilizing CRISPR/Cas9 gene editing technologies, these knockout cell lines facilitate the investigation of JOSD2's role in various biological pathways and its contributions to disease phenotypes, particularly in cancer and neurodegenerative disorders.
The primary function of JOSD2 involves modulating stress responses and protein homeostasis within cells. By knocking out the JOSD2 gene, researchers can elucidate its effects on cellular viability, proliferation, and apoptosis under stress conditions. The mechanistic insights gained from these studies can advance our understanding of how dysregulation of JOSD2 contributes to pathophysiological states, paving the way for potential therapeutic interventions.
In research and clinical settings, the availability of JOSD2 Gene Knockout Cell Lines allows for hypothesis-driven experiments to assess drug efficacy, identify molecular targets, and possibly develop biomarkers for disease states that involve JOSD2 aberration. Compared to traditional knockout models, these cell lines offer higher efficiency, reproducibility, and ease of use, thus accelerating the pace of research.
The unique selling points of JOSD2 Gene Knockout Cell Lines include their high fidelity, validated performance in various assays, and the support of comprehensive technical documentation to aid in experimental design and application. For researchers and clinicians, utilizing these specialized cell lines can lead to significant advancements in understanding gene function and developing novel treatments.
Our company brings extensive expertise in genetic engineering and cell line development, ensuring that our products meet rigorous scientific standards. With a commitment to supporting groundbreaking research, we offer a reliable resource for the scientific community to drive discoveries that impact human health.
Please note that all services are for research use only. Not intended for any clinical use.
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