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Ifngr1 Knockout Cell Lines

Gene: Ifngr1

Official Full Name: interferon gamma receptor 1provided by MGI

Gene Summary: Predicted to enable type II interferon receptor activity. Involved in glial cell activation; negative regulation of amyloid-beta clearance; and positive regulation of macromolecule metabolic process. Acts upstream of or within defense response to virus. Predicted to be located in dendrite and vesicle. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; bone; cerebral cortex; female reproductive system; and liver. Used to study osteoporosis. Human ortholog(s) of this gene implicated in asthma; hepatitis B; immunodeficiency 27A; immunodeficiency 27B; and tuberculosis. Orthologous to human IFNGR1 (interferon gamma receptor 1). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01088 Ifngr1 Knockout cell line (BV2) Mouse Ifngr1 1:3~1:5 Negative Online Inquiry

Background

Ifngr1 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the role of the Interferon gamma receptor 1 (Ifngr1) gene in various biological processes. These cell lines are created through the application of CRISPR-Cas9 gene editing technology, resulting in the precise knockout of the Ifngr1 gene, which encodes a vital receptor involved in immune responses, particularly in mediating the effects of interferon gamma. By eliminating this receptor, researchers can explore the downstream effects on cell signaling pathways, immune cell activation, and responses to viral and bacterial infections.

One of the key functions of these cell lines lies in their ability to simulate a state of immune deficiency, allowing for detailed investigation of pathogen interactions and immune response dynamics. They provide critical insights into autoimmune diseases, infections, and cancer biology. In clinical research, Ifngr1 knockout models can be employed to assess the effectiveness of novel therapeutic interventions aimed at modulating immune responses, providing a valuable tool for drug development.

What sets Ifngr1 Gene Knockout Cell Lines apart from other available models is their precision and the reliability of the CRISPR-Cas9 editing method. Unlike traditional knockout methodologies, which may result in off-target effects, our product ensures a highly specific gene disruption, thereby allowing for reproducible and consistent experimental outcomes. Furthermore, these cell lines are provided with comprehensive validation data, ensuring researchers can confidently rely on their performance in experimental settings.

Researchers, clinicians, and biopharmaceutical professionals will find immense value in the Ifngr1 Gene Knockout Cell Lines, as they enhance the ability to decipher complex immune mechanisms and support the development of innovative therapies. Our commitment to quality research tools is backed by extensive expertise in genetic engineering and cell line generation, ensuring that we deliver products that not only meet scientific demands but also drive progress in biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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