Gene: ITM2B
Official Full Name: integral membrane protein 2Bprovided by HGNC
Gene Summary: Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33228 | ITM2B Knockout cell line (HeLa) | Human | ITM2B | 1:3~1:6 | Negative | Online Inquiry |
KO33229 | ITM2B Knockout cell line (HCT 116) | Human | ITM2B | 1:2~1:4 | Negative | Online Inquiry |
KO33230 | ITM2B Knockout cell line (HEK293) | Human | ITM2B | 1:3~1:6 | Negative | Online Inquiry |
KO33231 | ITM2B Knockout cell line (A549) | Human | ITM2B | 1:3~1:4 | Negative | Online Inquiry |
ITM2B Gene Knockout Cell Lines are genetically modified cell lines in which the ITM2B gene has been specifically disrupted or “knocked out.” The ITM2B gene encodes for the integral membranes protein, which is involved in various cellular processes, including amyloid precursor protein regulation and neurotransmitter signaling. The knockout technique typically utilizes CRISPR-Cas9 technology or similar gene editing tools, enabling precise modifications that allow researchers to study the functional roles of the ITM2B gene in both normal and pathological conditions.
These cell lines serve as invaluable tools for understanding the biological pathways associated with neurodegenerative diseases, particularly Alzheimer's disease, where ITM2B is believed to play a critical role. By eliminating the ITM2B gene, researchers can elucidate its contributions to amyloid plaque formation and the overall pathogenic mechanisms involved in neurodegeneration. Furthermore, these knockout cell lines facilitate the development of therapeutic strategies and assist in drug discovery processes.
The key advantages of using ITM2B Gene Knockout Cell Lines include their customization potential and reproducibility. Unlike traditional knockout approaches which may involve labor-intensive methodologies and variable results, these cell lines provide standardized systems, ensuring consistency across experiments. This level of precision and efficiency makes them particularly attractive compared to other alternatives.
Researchers and clinicians utilizing ITM2B Gene Knockout Cell Lines benefit from a powerful model that enhances understanding of complex diseases, ultimately accelerating the path from discovery to therapeutic application. Our company specializes in developing high-quality, reliable biological tools, guaranteeing superior performance and supporting groundbreaking research efforts in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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