Gene: IQCB1
Official Full Name: IQ motif containing B1provided by HGNC
Gene Summary: This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32965 | IQCB1 Knockout cell line (HeLa) | Human | IQCB1 | 1:3~1:6 | Negative | Online Inquiry |
KO32966 | IQCB1 Knockout cell line (HCT 116) | Human | IQCB1 | 1:2~1:4 | Negative | Online Inquiry |
KO32967 | IQCB1 Knockout cell line (HEK293) | Human | IQCB1 | 1:3~1:6 | Negative | Online Inquiry |
KO32968 | IQCB1 Knockout cell line (A549) | Human | IQCB1 | 1:3~1:4 | Negative | Online Inquiry |
IQCB1 Gene Knockout Cell Lines represent a cutting-edge tool for researchers focused on investigating the biological roles of the IQCB1 gene in various diseases, particularly those related to retinal degeneration. These cell lines have been meticulously engineered to lack functional IQCB1 gene expression, providing an invaluable model for studying the gene's functions and its implications in cellular processes such as signal transduction, cytoskeletal organization, and cellular differentiation.
The primary function of these knockout cell lines is to facilitate detailed investigations into the biochemical pathways influenced by IQCB1. By lacking this gene, the cell lines allow scientists to assess the resultant phenotypic changes and molecular disruptions, enabling the elucidation of IQCB1's role in cell physiology and pathophysiology. The mechanisms through which IQCB1 operates can be scrutinized at multiple levels, including transcriptional regulation, protein interactions, and the impact on cellular responses to stress or injury.
The scientific importance of IQCB1 Gene Knockout Cell Lines is vast, with applications spanning fundamental research, drug discovery, and the development of therapeutic strategies for retinal diseases. In clinical settings, these models can mimic the particularities of disease states, providing a platform for testing new pharmacological agents targeting IQCB1-related pathways. By leveraging these knockout cell lines, researchers can gain insights that drive innovation in gene therapy or regenerative medicine.
One standout advantage of the IQCB1 Gene Knockout Cell Lines is their high specificity and reliability, distinguishing them from conventional models that may not express desired mutations. Furthermore, these cell lines are compatible with a wide range of assays and customization options for experimental design, increasing their versatility in research applications.
For researchers and clinicians alike, the value of IQCB1 Gene Knockout Cell Lines lies in their potential to accelerate discoveries and enhance understanding of gene function in health and disease. Utilizing these advanced models can significantly reduce the time and resources needed to transition from basic science to practical applications.
Our company has a proven track record in providing top-tier biological products that support the scientific community. With a commitment to quality and innovation, we offer these knockout cell lines as an integral part of your research toolkit, designed to empower your findings and facilitate groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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