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INTS14 Knockout Cell Lines

Gene: INTS14

Official Full Name: integrator complex subunit 14provided by HGNC

Gene Summary: Predicted to be involved in snRNA 3'-end processing. Located in cytoplasm. Part of integrator complex. Is active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25733 INTS14 Knockout cell line (HeLa) Human INTS14 1:3~1:6 Negative Online Inquiry
KO25734 INTS14 Knockout cell line (HCT 116) Human INTS14 1:2~1:4 Negative Online Inquiry
KO25735 INTS14 Knockout cell line (HEK293) Human INTS14 1:3~1:6 Negative Online Inquiry
KO25736 INTS14 Knockout cell line (A549) Human INTS14 1:3~1:4 Negative Online Inquiry

Background

INTS14 Gene Knockout Cell Lines are engineered mammalian cells that have been modified to disrupt the expression of the INTS14 gene, which is implicated in the processes of mRNA processing and nuclear regulation. These knockout cell lines provide researchers with a powerful tool to dissect the biological roles of INTS14, facilitating investigations into gene function, pathway analysis, and the cellular consequences of its absence.

The primary mechanism by which INTS14 knockout cell lines operate lies in the targeted deletion of the INTS14 gene, achieved through techniques such as CRISPR-Cas9 or homologous recombination. This genetic alteration leads to the loss of INTS14 protein expression, thereby allowing for observation of downstream effects on mRNA metabolism, transcription, and cellular stress responses. Researchers can utilize these cell lines to better understand how INTS14 influences gene regulatory networks and contributes to various cellular processes, making them invaluable in basic and applied research.

The scientific importance of these cell lines cannot be overstated, as they have applications in cancer biology, neurobiology, and drug discovery. By studying the INTS14 knockout cell lines, scientists can unveil potential therapeutic targets for diseases linked to RNA metabolism dysregulation. Moreover, these models pave the way for advances in gene therapy approaches and enhance the reliability of translational research findings.

Compared to traditional models, such as wild-type cell lines, INTS14 knockout cell lines eliminate confounding variables, providing researchers with a more precise understanding of INTS14 function. Additionally, these cell lines come with extensive characterization data, ensuring reproducibility and reliability in experimental setups, which can vastly improve research efficiency.

In offering INTS14 Gene Knockout Cell Lines, our company capitalizes on extensive experience in genetic engineering and cell line development, enabling us to provide high-quality, fully characterized products tailored to advance scientific discovery. Our commitment to innovation and excellence positions researchers to uncover novel insights that could lead to breakthroughs in various fields of biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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