Gene: INTS12
Official Full Name: integrator complex subunit 12provided by HGNC
Gene Summary: INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16902 | INTS12 Knockout cell line (HeLa) | Human | INTS12 | 1:3~1:6 | Negative | Online Inquiry |
KO16903 | INTS12 Knockout cell line (HCT 116) | Human | INTS12 | 1:2~1:4 | Negative | Online Inquiry |
KO16904 | INTS12 Knockout cell line (HEK293) | Human | INTS12 | 1:3~1:6 | Negative | Online Inquiry |
INTS12 Gene Knockout Cell Lines are specialized cell models engineered to disrupt the function of the INTS12 gene, a crucial component of the Integrator complex that plays a pivotal role in RNA processing and transcription regulation. These cell lines are invaluable tools for investigating the downstream effects of INTS12 loss on gene expression, cellular differentiation, and various metabolic pathways. The knockout mechanism is achieved through advanced CRISPR-Cas9 technology, which enables precise editing of the genomic DNA, resulting in a complete gene disruption.
The primary function of INTS12 Gene Knockout Cell Lines is to facilitate research into the biological roles of the INTS12 gene. By providing a controlled environment where researchers can monitor the outcomes of gene inactivation, these cell lines allow scientists to delineate the molecular pathways mediated by INTS12. This includes studying its implications in diseases, such as cancer and neurodegenerative disorders, where aberrant RNA processing can significantly impact cellular function.
In clinical and research settings, the significance of INTS12 Gene Knockout Cell Lines lies in their capacity to serve as models for understanding disease mechanisms and drug responses. They offer a critical platform for functional genomics studies, target validation, and the development of potential therapeutic strategies. Compared to traditional knockout approaches, our cell lines benefit from robust validation processes, ensuring high specificity and efficiency, which means researchers can trust in the accuracy of the findings derived from these models.
What sets our INTS12 Gene Knockout Cell Lines apart from alternatives is not only their precision in gene targeting but also the comprehensive documentation and experimental validation that accompany them. Each cell line is rigorously characterized, allowing users to have confidence in their reproducibility and applicability in varied experimental conditions. With the growing interest in gene function elucidation and the role of RNA metabolism in human health, these cell lines offer unmatched opportunities for groundbreaking research.
As leaders in biotechnological innovations, our company is committed to delivering high-quality biological products that empower researchers and clinicians alike. Our extensive expertise in genetic engineering and cell line development ensures that we provide tools that not only advance scientific discovery but also enhance the pursuit of innovative therapies.
Please note that all services are for research use only. Not intended for any clinical use.
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