Gene: INSR
Official Full Name: insulin receptorprovided by HGNC
Gene Summary: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10736 | INSR Knockout cell line (HeLa) | Human | INSR | 1:3~1:6 | Negative | Online Inquiry |
KO10737 | INSR Knockout cell line (HCT 116) | Human | INSR | 1:2~1:4 | Negative | Online Inquiry |
KO10738 | INSR Knockout cell line (HEK293) | Human | INSR | 1:3~1:6 | Negative | Online Inquiry |
KO10739 | INSR Knockout cell line (A549) | Human | INSR | 1:3~1:4 | Negative | Online Inquiry |
INSR Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to study the insulin receptor (INSR) function and its implications in metabolic diseases such as diabetes and obesity. Through precise gene editing techniques, these cell lines have been optimized to lack functional INSR, providing a valuable tool for researchers aiming to elucidate the complex biochemical pathways regulated by insulin signaling.
The primary function of the INSR Gene Knockout Cell Lines is to allow scientists to assess the consequences of insulin receptor deficiency on cellular processes. By removing the INSR gene, researchers can investigate the alterations in glucose metabolism, lipid synthesis, and cell proliferation, thereby gaining insights into insulin resistance mechanisms. This cell line serves as an essential model for examining how cellular responses to insulin are affected, enabling the study of potential therapeutic interventions in insulin-related disorders.
The scientific importance of these cell lines cannot be overstated; they play a critical role in both basic and applied research. Clinically, understanding the nuances of insulin signaling through these models can lead to advancements in diabetes treatment modalities and innovations in metabolic disorder therapies. Research involving the INSR Gene Knockout Cell Lines has implications for drug development, as it connects molecular pathways to potential pharmacological targets.
One of the unique selling points of these cell lines is their specificity and reliability compared to other models, enabling researchers to achieve consistent results and enhanced reproducibility in their experiments. Furthermore, these knockout lines are validated for functional assays, providing confidence in experimental outcomes and minimizing the variation often encountered with alternative models.
Researchers, clinicians, and pharmaceutical companies will find significant value in employing the INSR Gene Knockout Cell Lines to advance their understanding of insulin-related diseases. The ability to model specific mutations and their downstream effects offers unparalleled opportunities for innovative research and potential clinical breakthroughs.
With a commitment to excellence in biological product development, our company is recognized for its expertise in providing high-quality genetic tools designed to enhance the capabilities of scientific research and discovery. Through our advanced methodologies, we ensure that researchers have the resources they need to drive the future of medical science.
Please note that all services are for research use only. Not intended for any clinical use.
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