Gene: INPP5K
Official Full Name: inositol polyphosphate-5-phosphatase Kprovided by HGNC
Gene Summary: This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16912 | INPP5K Knockout cell line (HeLa) | Human | INPP5K | 1:3~1:6 | Negative | Online Inquiry |
KO16913 | INPP5K Knockout cell line (HCT 116) | Human | INPP5K | 1:2~1:4 | Negative | Online Inquiry |
KO16914 | INPP5K Knockout cell line (HEK293) | Human | INPP5K | 1:3~1:6 | Negative | Online Inquiry |
KO39186 | INPP5K Knockout cell line (A549) | Human | INPP5K | 1:3~1:4 | Negative | Online Inquiry |
INPP5K Gene Knockout Cell Lines are precisely engineered cell cultures in which the inositol polyphosphate-5-phosphatase K (INPP5K) gene has been inactivated, providing invaluable tools for the study of cellular processes regulated by this critical enzyme. INPP5K is involved in phosphoinositide signaling pathways that play key roles in several physiological processes, including cell growth, proliferation, and apoptosis. By utilizing these gene knockout cell lines, researchers can delineate the specific contributions of INPP5K in various cellular contexts, leading to a better understanding of its role in disease mechanisms, particularly in cancer and metabolic disorders.
These knockout cell lines function by eliminating the production of the INPP5K protein, which interrupts its downstream signaling pathways. This allows researchers to observe the resultant phenotypic changes compared to wild-type cell lines, ultimately elucidating the biological significance of INPP5K. In research and clinical settings, these models can be employed for high-throughput drug screening, functional genomics studies, and pathway analysis, providing critical insights into targeted therapies that may modulate INPP5K activity.
The advantages of INPP5K Gene Knockout Cell Lines lie in their specificity and reproducibility. Unlike traditional methods that may yield off-target effects, these knockout lines are created using CRISPR-Cas9 technology, ensuring precise modifications. This results in a more reliable research environment, where scientists can confidently attribute observed cellular responses directly to the absence of INPP5K. Furthermore, these cell lines are readily available and easy to culture, saving valuable time for researchers.
As leading producers of cutting-edge biological tools, our company specializes in the development and production of high-quality cell lines that enable researchers and clinicians to explore novel therapeutic avenues. With a commitment to innovation, quality, and customer support, we are dedicated to advancing scientific discovery and ultimately improving patient outcomes in a variety of fields.
Please note that all services are for research use only. Not intended for any clinical use.
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