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IMMP1L Knockout Cell Lines

Gene: IMMP1L

Official Full Name: inner mitochondrial membrane peptidase subunit 1provided by HGNC

Gene Summary: The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 and IMP2 (IMMP2L; MIM 605977) are the catalytic subunits of the IMP complex (Burri et al., 2005 [PubMed 15814844]).[supplied by OMIM, Sep 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00410 IMMP1L Knockout cell line (HEK293) Human IMMP1L 1:3~1:6 Negative Online Inquiry
KO16948 IMMP1L Knockout cell line (HeLa) Human IMMP1L 1:3~1:6 Negative Online Inquiry
KO16949 IMMP1L Knockout cell line (HCT 116) Human IMMP1L 1:2~1:4 Negative Online Inquiry
KO16950 IMMP1L Knockout cell line (A549) Human IMMP1L 1:3~1:4 Negative Online Inquiry

Background

IMMP1L Gene Knockout Cell Lines are an advanced biological tool specifically engineered to facilitate the study of the mitochondrial inner membrane peptidase 1-like (IMMP1L) gene. By utilizing CRISPR/Cas9 technology, these knockout cell lines have been meticulously developed to disable the expression of the IMMP1L gene, allowing researchers to investigate its role in cellular processes, mitochondrial function, and various diseases more effectively.

The key function of IMMP1L Gene Knockout Cell Lines lies in their ability to provide a controlled environment that isolates the effects of IMMP1L loss. This is crucial for understanding how the gene contributes to mitochondrial protein processing and the implications that may arise from its dysfunction, which can be pivotal in conditions such as neurodegenerative diseases and metabolic disorders. The mechanisms underpinning their operation involve the targeted editing of the genomic DNA at the IMMP1L locus, leading to a permanent disruption of the gene’s coding sequence.

The scientific importance of these cell lines extends beyond basic research; they have significant applications in drug discovery and therapeutics. By utilizing these knockout models, researchers can assess potential therapeutic targets and evaluate drug responses in a more biologically relevant context, ensuring that findings are translatable to clinical scenarios.

Compared to alternative models, such as transient transfection systems or non-targeted gene disruption methods, IMMP1L Gene Knockout Cell Lines offer enhanced stability, reproducibility, and genetic fidelity. This results in more reliable experimental outcomes, greatly benefiting studies focused on mitochondrial pathophysiology.

For researchers, clinicians, and pharmaceutical developers, these knockout cell lines are invaluable, offering the capability to dissect complex biological pathways and develop targeted therapies with greater efficiency. By using a robust model that closely mimics physiological conditions, users can gain deeper insights that drive innovation in mitochondrial research and therapeutic strategies.

At [Your Company Name], we pride ourselves on our commitment to providing high-quality biological products that empower cutting-edge research. Our expertise in gene editing technologies and cell line development ensures that our offerings meet the rigorous demands of the scientific community, facilitating significant advancements in the understanding and treatment of human diseases.

Please note that all services are for research use only. Not intended for any clinical use.

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