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IKZF4 Knockout Cell Lines

Gene: IKZF4

Official Full Name: IKAROS family zinc finger 4provided by HGNC

Gene Summary: Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16967 IKZF4 Knockout cell line (HeLa) Human IKZF4 1:3~1:6 Negative Online Inquiry
KO16968 IKZF4 Knockout cell line (HCT 116) Human IKZF4 1:2~1:4 Negative Online Inquiry
KO16969 IKZF4 Knockout cell line (HEK293) Human IKZF4 1:3~1:6 Negative Online Inquiry
KO16970 IKZF4 Knockout cell line (A549) Human IKZF4 1:3~1:4 Negative Online Inquiry

Background

IKZF4 Gene Knockout Cell Lines are genetically modified cell lines that specifically disable the IKZF4 gene, a key regulator involved in immune responses, differentiation of lymphocytes, and hematopoiesis. Utilizing CRISPR-Cas9 gene-editing technology, these cell lines provide a controlled environment for researchers to investigate the biological functions and pathways associated with IKZF4. By creating knockout lines, scientists can assess the phenotypic consequences of loss of IKZF4 function, facilitating insights into its role in various immune-mediated disorders.

The primary function of the IKZF4 Gene Knockout Cell Lines is to serve as a tool for elucidating the molecular mechanisms underlying immune cell development and function. By studying these modified cell lines, researchers can explore how alterations in the IKZF4 gene impact cellular behavior, including proliferation, apoptosis, and cytokine production. This understanding is pivotal in advancing our knowledge of diseases such as autoimmune disorders, lymphomas, and other hematological malignancies. Additionally, IKZF4 has been implicated in therapeutic resistance, making these knockout lines valuable in both basic and applied research settings.

Compared to other gene-editing alternatives, such as RNA interference or traditional knockdown approaches, the IKZF4 Gene Knockout Cell Lines offer several distinct advantages. The CRISPR-Cas9 method provides a permanent and efficient alteration of the target gene, enabling stable expression studies without the complications associated with transient knockdown methods. This increases reproducibility and reliability of experimental results, which are crucial for rigorous scientific investigation.

The IKZF4 Gene Knockout Cell Lines represent a significant advancement for researchers and clinicians seeking to uncover the complexities of immune system regulation. By enabling a deeper understanding of disease mechanisms and potential therapeutic targets, these cell lines empower users to make more informed decisions in both research and clinical applications.

Our company is committed to advancing research in the biological sciences by providing high-quality, reliable research products like the IKZF4 Gene Knockout Cell Lines. With a focus on precision and innovation, we are dedicated to supporting the scientific community in their quest for biological discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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