Gene: IGL
Official Full Name: immunoglobulin lambda locusprovided by HGNC
Gene Summary: Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37073 | IGL Knockout cell line (HeLa) | Human | IGL | 1:3~1:6 | Negative | Online Inquiry |
KO37074 | IGL Knockout cell line (HCT 116) | Human | IGL | 1:2~1:4 | Negative | Online Inquiry |
KO37075 | IGL Knockout cell line (HEK293) | Human | IGL | 1:3~1:6 | Negative | Online Inquiry |
KO37076 | IGL Knockout cell line (A549) | Human | IGL | 1:3~1:4 | Negative | Online Inquiry |
IGL Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate targeted gene disruption, providing researchers with vital tools to study gene function and regulation. These cell lines are created through the precise application of CRISPR-Cas9 technology, enabling the introduction of specific mutations that lead to the inactivation of target genes. This process not only allows for the investigation of gene knockout effects but also helps elucidate the pathways and molecular mechanisms influenced by the gene in question.
The primary function of IGL Gene Knockout Cell Lines lies in their ability to generate cellular models that mimic disease states or cellular responses to environmental stimuli. By effectively isolating the phenotype associated with the loss of a specific gene, researchers can uncover critical insights necessary for understanding complex biological processes and disease mechanisms. This capability is invaluable not only in basic research but also possesses significant implications in drug discovery and development, as well as in personalized medicine.
One of the standout advantages of IGL Gene Knockout Cell Lines is their high specificity and efficiency, which often surpasses traditional gene-editing methods. In comparison to older techniques like RNA interference, these knockout cell lines yield more permanent and stable genetic alterations, allowing for long-term studies that can lead to more robust data. Furthermore, they are rigorously validated for off-target effects, ensuring high reproducibility – a key consideration in any scientific experimentation.
Researchers and clinicians can greatly benefit from utilizing IGL Gene Knockout Cell Lines, given their role in accelerating the understanding of gene function and their extensive applications across various disciplines, such as oncology, immunology, and developmental biology. They serve as essential platforms for the testing of therapeutic interventions and contribute to the advancement of gene therapy research.
Our company brings extensive expertise in genetic engineering and cell biology, delivering high-quality, well-characterized knockout cell lines, paired with exceptional customer support. We are committed to enabling your research and clinical endeavors with innovative solutions that meet the evolving demands of modern biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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