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IDI1 Knockout Cell Lines

Gene: IDI1

Official Full Name: isopentenyl-diphosphate delta isomerase 1provided by HGNC

Gene Summary: IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37120 IDI1 Knockout cell line (HeLa) Human IDI1 1:3~1:6 Negative Online Inquiry
KO37121 IDI1 Knockout cell line (HCT 116) Human IDI1 1:2~1:4 Negative Online Inquiry
KO37122 IDI1 Knockout cell line (HEK293) Human IDI1 1:3~1:6 Negative Online Inquiry
KO37123 IDI1 Knockout cell line (A549) Human IDI1 1:3~1:4 Negative Online Inquiry

Background

IDI1 Gene Knockout Cell Lines are advanced biological tools designed to facilitate the exploration of IDI1 (Isopentenyl Diphosphate Isomerase 1) gene functions in a controlled cellular environment. The creation of these knockout cell lines involves precise genome editing technologies, such as CRISPR/Cas9, allowing researchers to specifically target and disrupt the IDI1 gene, thereby enabling detailed studies on the gene's role in cellular processes and metabolic pathways.

The key function of IDI1 is to catalyze the conversion of isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP), crucial intermediates in the biosynthesis of isoprenoids and other essential cellular components. By analyzing the knockout cell lines, scientists can investigate the consequences of IDI1 disruption, shedding light on metabolic changes, cell proliferation, and signaling pathways related to isoprenoid synthesis. This research is especially significant in cancer studies and metabolic disorders where dysregulation of isoprenoid pathways is often observed.

In clinical and research settings, these IDI1 Gene Knockout Cell Lines are invaluable for developing targeted therapies and understanding disease mechanisms at a molecular level. Compared to other knockout models, our lines are characterized by high specificity, reproducibility, and ease of use, allowing for rapid experimental setup and reliable outcome measurement.

Researchers and clinicians will find these cell lines particularly advantageous for their ability to model diseases in vitro, assess the impact of potential drug candidates, and provide insights into fundamental biological processes. The disruption of the IDI1 gene opens doors to new therapeutic avenues and offers a deeper understanding of isoprenoid metabolism, making it a critical asset in contemporary biomedical research.

Our company stands at the forefront of genetic engineering and cell line development, backed by a team of experts dedicated to providing high-quality biological products that empower scientific discovery. We reinforce our commitment to innovation and reliability, ensuring that our IDI1 Gene Knockout Cell Lines effectively meet the evolving needs of researchers in their quest to unravel the complexities of life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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