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Hsd11b1 Knockout Cell Lines

Gene: Hsd11b1

Official Full Name: hydroxysteroid 11-beta dehydrogenase 1provided by MGI

Gene Summary: Enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity. Acts upstream of or within lung development. Predicted to be located in apical part of cell and nuclear membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study cortisone reductase deficiency 2. Human ortholog(s) of this gene implicated in cortisone reductase deficiency (multiple); hypertension (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2025]

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Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01074 Hsd11b1 Knockout cell line (RAW 264.7) Mouse Hsd11b1 Negative Online Inquiry

Background

Hsd11b1 Gene Knockout Cell Lines are specialized in vitro models designed to help researchers investigate the biological roles of the Hsd11b1 gene, which is critical in the metabolism of corticosteroids and plays an essential role in the regulation of physiological processes related to stress responses, metabolism, and inflammation. By employing CRISPR/Cas9 gene editing technology, these cell lines have been precisely engineered to disable the Hsd11b1 gene, allowing for the exploration of its functional consequences in a controlled environment.

The primary function of these knockout cell lines lies in their capacity to delineate the pathways impacted by the absence of Hsd11b1, thereby facilitating studies on glucocorticoid signaling and its implications in metabolic syndromes, obesity, and stress-related disorders. Researchers can utilize these cell lines to evaluate drug responses, investigate gene interactions, and examine the cellular mechanisms underlying various pathophysiological conditions.

From a scientific perspective, Hsd11b1 Gene Knockout Cell Lines serve as invaluable tools for both basic research and drug development, providing insights that can translate into clinical applications. Their use can lead to the identification of novel therapeutic targets or biomarkers that may assist in the development of personalized medicine strategies for conditions influenced by corticosteroid metabolism.

Compared to traditional cell lines, the Hsd11b1 knockout models present several advantages, including enhanced specificity in research outcomes due to the complete absence of the target gene, which leads to clearer interpretation of experimental data. Additionally, these cell lines are robust and easy to maintain, making them accessible for high-throughput screening applications.

Researchers and clinicians will find the Hsd11b1 Gene Knockout Cell Lines a valuable addition to their experimental toolkit, as they offer a powerful mechanism to uncover novel insights into the molecular underpinnings of health and disease. Our company, with a commitment to advancing scientific discovery, specializes in producing high-quality biological products that empower researchers to achieve groundbreaking findings in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

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