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HYAL2 Knockout Cell Lines

Gene: HYAL2

Official Full Name: hyaluronidase 2provided by HGNC

Gene Summary: This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33947 HYAL2 Knockout cell line (HeLa) Human HYAL2 1:3~1:6 Negative Online Inquiry
KO33948 HYAL2 Knockout cell line (HCT 116) Human HYAL2 1:2~1:4 Negative Online Inquiry
KO33949 HYAL2 Knockout cell line (HEK293) Human HYAL2 1:3~1:6 Negative Online Inquiry
KO33950 HYAL2 Knockout cell line (A549) Human HYAL2 1:3~1:4 Negative Online Inquiry

Background

HYAL2 Gene Knockout Cell Lines are specialized cellular models designed to facilitate research in the field of molecular biology, specifically targeting the study of hyaluronan metabolism and its implications in various pathophysiological conditions. By employing targeted gene editing techniques such as CRISPR-Cas9, these cell lines exhibit a complete knockout of the HYAL2 gene, which encodes the enzyme responsible for the degradation of hyaluronan, a vital polysaccharide involved in cell signaling, wound healing, and tissue repair.

The key function of HYAL2 gene knockout cell lines lies in their ability to provide researchers with a stable platform to investigate the biological consequences of hyaluronan accumulation and the resultant alterations in cellular behavior. The absence of HYAL2 allows for a clearer understanding of hyaluronan’s role in oncogenesis, inflammation, and tissue regeneration. By utilizing these cell lines, scientists can explore how changes in hyaluronan levels affect the tumor microenvironment, immune system interactions, and cellular differentiation pathways.

In clinical research and therapeutic development, the importance of HYAL2 gene knockout cell lines is underscored by their potential applications in cancer treatment, regenerative medicine, and cartilage repair strategies. Researchers can leverage these models to evaluate drug efficacy, test novel therapeutic approaches, and understand disease mechanisms at a cellular level.

What sets our HYAL2 Gene Knockout Cell Lines apart from alternative models is the precision and reliability achieved through stringent quality control processes, ensuring high reproducibility in experimental results. Additionally, our cell lines are readily accessible with robust technical support, allowing users to integrate them seamlessly into their research workflows without the initial challenges of establishing knockout models.

For researchers and clinicians dedicated to advancing the understanding of extracellular matrix components and their roles in health and disease, these cell lines represent an invaluable tool. Our company focuses on delivering cutting-edge biological products backed by years of expertise in gene editing technologies and cellular biology, enabling you to accelerate your discoveries and enhance therapeutic innovations.

Please note that all services are for research use only. Not intended for any clinical use.

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