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HSPBP1 Knockout Cell Lines

Gene: HSPBP1

Official Full Name: HSPA (Hsp70) binding protein 1provided by HGNC

Gene Summary: Enables molecular sequestering activity and ubiquitin protein ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Is active in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29029 HSPBP1 Knockout cell line (HeLa) Human HSPBP1 1:3~1:6 Negative Online Inquiry
KO29030 HSPBP1 Knockout cell line (HCT 116) Human HSPBP1 1:2~1:4 Negative Online Inquiry
KO29031 HSPBP1 Knockout cell line (HEK293) Human HSPBP1 1:3~1:6 Negative Online Inquiry
KO29032 HSPBP1 Knockout cell line (A549) Human HSPBP1 1:3~1:4 Negative Online Inquiry

Background

HSPBP1 Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate the in-depth study of the HSPBP1 gene, which encodes a co-chaperone involved in protein folding and maintenance of cellular homeostasis. These knockout cell lines are generated using advanced CRISPR/Cas9 gene-editing technology, ensuring precise insertion and deletion of genetic material, thus allowing researchers to effectively eliminate HSPBP1 expression and study the resultant phenotypic changes.

The primary mechanism of action revolves around the disruption of the HSPBP1 functional pathway, which plays a pivotal role in cellular stress responses and chaperone-mediated protein folding. By utilizing these knockout cell lines, researchers can investigate the consequences of HSPBP1 loss on numerous cellular processes, including apoptosis, signal transduction, and stress responses. This makes them invaluable for elucidating the gene's role in various diseases, particularly cancer and neurodegenerative disorders.

The scientific importance of HSPBP1 Gene Knockout Cell Lines is underscored by their broad applications in both research and clinical settings. They serve as critical tools in drug discovery, helping to identify potential therapeutic targets, and in biomarker discovery, potentially leading to novel diagnostic tools. Comparative analyses with wild-type cell lines enable researchers to delineate clear differences in cellular behavior, providing insights that could drive advancements in personalized medicine.

A distinct advantage of our HSPBP1 Gene Knockout Cell Lines is their robust validation through rigorous phenotypic and genotypic assessments, ensuring reliability that sets them apart from similar products on the market. Additionally, we provide a comprehensive support network to assist users in optimizing experimental conditions tailored to their specific research needs.

For researchers and clinicians alike, the value of HSPBP1 Gene Knockout Cell Lines lies in their capacity to significantly enhance the understanding of cellular mechanisms and the development of novel therapeutic strategies. Backed by our extensive expertise in cellular and molecular biology, we are committed to delivering high-quality biological products that empower research advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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