Home / HS2ST1 Knockout Cell Lines

HS2ST1 Knockout Cell Lines

Gene: HS2ST1

Official Full Name: heparan sulfate 2-O-sulfotransferase 1provided by HGNC

Gene Summary: Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32973 HS2ST1 Knockout cell line (HeLa) Human HS2ST1 1:3~1:6 Negative Online Inquiry
KO32974 HS2ST1 Knockout cell line (HCT 116) Human HS2ST1 1:2~1:4 Negative Online Inquiry
KO32975 HS2ST1 Knockout cell line (HEK293) Human HS2ST1 1:3~1:6 Negative Online Inquiry
KO32976 HS2ST1 Knockout cell line (A549) Human HS2ST1 1:3~1:4 Negative Online Inquiry

Background

HS2ST1 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the functional roles and regulatory mechanisms of the HS2ST1 gene, which is crucial in heparan sulfate biosynthesis. By utilizing CRISPR/Cas9 technology to create precise gene disruptions, these cell lines allow researchers to effectively evaluate the implications of HS2ST1 knockout on various biochemical pathways and cellular responses.

The fundamental mechanism of these knockout cell lines lies in producing a loss-of-function mutation that eliminates the expression of the HS2ST1 gene. This genetic alteration can significantly impact cell signaling, adhesion, and matrix interactions, which are vital in developmental biology, cancer research, and regenerative medicine. By studying these changes, researchers can uncover the HS2ST1 gene’s role in pathological processes, thus contributing valuable insights into potential therapeutic targets.

The scientific importance of HS2ST1 Gene Knockout Cell Lines extends into diverse research areas, including the study of glycosaminoglycan modifications and their associations with various diseases. The availability of these cell lines offers a powerful tool for drug discovery, biomarker identification, and the elucidation of disease mechanisms. The precise gene knockout methodology used ensures high reliability and reproducibility of experimental results, making these models particularly advantageous in clinical research settings.

Compared to alternative models, HS2ST1 Gene Knockout Cell Lines provide high specificity and control over genetic manipulation, significantly enhancing experimental outcomes. Researchers can conduct detailed analyses with minimized variability, leading to more robust data and conclusions. Furthermore, the ease of use and adaptability of these cell lines makes them suitable for both academic and industrial laboratories focused on translational research.

Valuable to researchers, clinicians, and biotechnology professionals, HS2ST1 Gene Knockout Cell Lines represent a significant investment in advancing genetic and biomedical research. They support the discovery of innovative therapies and foster a deeper understanding of cellular processes, positioning users at the forefront of scientific advancement. Our company is committed to providing high-quality biological products that empower researchers and clinicians alike, supported by a team of experts with extensive experience in cell line development and applications.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.