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HRC Knockout Cell Lines

Gene: HRC

Official Full Name: histidine rich calcium binding proteinprovided by HGNC

Gene Summary: This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08121 HRC Knockout cell line (HEK293) Human HRC 1:3~1:6 Negative Online Inquiry

Background

HRC Gene Knockout Cell Lines are a cutting-edge tool developed for the study of gene function and its implications in various biological processes. These cell lines have been genetically engineered to specifically disrupt the HRC gene, which encodes for important proteins involved in cellular functions such as calcium handling and apoptosis. This targeted knockout facilitates the investigation of the gene's role in diseases, including cardiac disorders and metabolic syndromes, by allowing researchers to observe resultant phenotypic changes in a controlled environment.

The primary mechanism of action involves the utilization of CRISPR-Cas9 technology, a powerful genome-editing tool that creates precise alterations in the DNA sequence of the HRC gene. This results in the complete loss of gene expression, enabling detailed functional assays to assess the impact of HRC deficiency on cellular behaviors such as proliferation, differentiation, and response to stimuli. With these gene knockout cell lines, researchers can elucidate the HRC gene's contribution to various pathways and its potential as a therapeutic target.

The scientific significance of HRC Gene Knockout Cell Lines extends to both research and clinical applications, making them instrumental in drug discovery, developmental biology, and understanding the pathophysiology of diseases. These cell lines enable scientists to model human diseases more accurately, thereby improving the prospects for the development of targeted therapies.

Compared to traditional knockout models, HRC Gene Knockout Cell Lines provide numerous advantages, including ease of use, reproducibility, and the ability to rapidly generate data relevant to human health. Furthermore, their specific targeting of the HRC gene allows for more nuanced investigations without the confounding factors often present in whole-animal models.

For researchers and clinicians seeking to deepen their understanding of gene function or to develop new therapeutic approaches, HRC Gene Knockout Cell Lines represent a valuable resource. They not only enhance the efficiency of experimental design but also open new avenues for innovation in treatment strategies. Our company has a longstanding expertise in the production and design of tailored biological products and is committed to advancing research frontiers through high-quality tools that foster scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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