Gene: HOXC4
Official Full Name: homeobox C4provided by HGNC
Gene Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37220 | HOXC4 Knockout cell line (HeLa) | Human | HOXC4 | 1:3~1:6 | Negative | Online Inquiry |
KO37221 | HOXC4 Knockout cell line (HEK293) | Human | HOXC4 | 1:3~1:6 | Negative | Online Inquiry |
KO37222 | HOXC4 Knockout cell line (A549) | Human | HOXC4 | 1:3~1:4 | Negative | Online Inquiry |
HOXC4 Gene Knockout Cell Lines are sophisticated genetic models designed for the study of HOXC4 gene function and its implications in various biological processes. The HOXC4 gene, a member of the homeobox family, plays a crucial role in developmental processes and has been linked to several types of cancer. By utilizing CRISPR-Cas9 technology, these knockout cell lines facilitate the complete disruption of the HOXC4 gene, thereby providing researchers with a powerful tool to elucidate the gene’s specific roles, mechanisms of action, and potential pathways of involvement in pathology.
The key function of HOXC4 Gene Knockout Cell Lines lies in their ability to allow for the evaluation of cellular processes such as differentiation, proliferation, and apoptosis in the absence of functional HOXC4. Researchers can assess changes in gene expression and cellular behavior by comparing these knockout lines with wild-type controls, leading to a deeper understanding of the gene's contribution to normal and aberrant cellular functions.
The scientific significance of these knockout cell lines extends to both basic research and clinical applications. They serve as invaluable resources for understanding developmental biology, epigenetics, and tumor biology, where aberrations in HOXC4 expression can influence tumor progression and response to therapies. Consequently, findings derived from studies using HOXC4 knockout models may contribute to the identification of novel therapeutic targets or biomarkers for cancers associated with HOXC4 dysregulation.
Compared to alternative gene-editing approaches, HOXC4 Gene Knockout Cell Lines offer several advantages. They provide a reliable and consistent genetic background for experimental reproducibility, are easily proliferated in vitro, and can be employed in high-throughput screening assays. Additionally, the precision of CRISPR-Cas9 techniques minimizes off-target effects, ensuring that observed phenotypes are attributable to the specific knockout of the HOXC4 gene.
For researchers and clinicians aiming to advance their understanding of gene function and disease mechanisms, HOXC4 Gene Knockout Cell Lines represent a crucial asset. With their unique capabilities, they empower users to conduct impactful research that can lead to discoveries with potential translational value.
Our company is dedicated to providing high-quality biological products, supported by extensive expertise in gene editing technologies. We strive to empower researchers by delivering innovative solutions that drive scientific progress and transcend the boundaries of current biological knowledge.
Please note that all services are for research use only. Not intended for any clinical use.
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